Chemistry:HCTU
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Names | |
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IUPAC name
O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
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Other names
2-(6-Chloro-1H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
EC Number |
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PubChem CID
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Properties | |
C11H15ClF6N5OP | |
Molar mass | 413.69 g·mol−1 |
Appearance | White to off white powder |
Melting point | >185 °C |
Hazards | |
GHS pictograms | |
GHS Signal word | Warning |
H228, H302, H315, H319, H335 | |
P210, P240, P241, P261, P264, P270, P271, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362, P370+378, P403+233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
HCTU is an aminium coupling reagent used in peptide synthesis. It is analogous to HBTU.[1] The HOBt moiety has a chlorine in the 6 position which improves reaction rates and the synthesis of difficult couplings[2][3]
References
- ↑ Marder, Oleg; Shvo, Youval; Albericio, Fernando (2003-08-12). "HCTU and TCTU: New Coupling Reagents — Development and Industrial Aspects" (in en). ChemInform 34 (32). doi:10.1002/chin.200332258. ISSN 1522-2667.
- ↑ Hood, Christina A.; Fuentes, German; Patel, Hirendra; Page, Karen; Menakuru, Mahendra; Park, Jae H. (2008-01-01). "Fast conventional Fmoc solid-phase peptide synthesis with HCTU" (in en). Journal of Peptide Science 14 (1): 97–101. doi:10.1002/psc.921. ISSN 1099-1387. PMID 17890639.
- ↑ Sabatino, Giuseppina; Mulinacci, Barbara; Alcaro, Maria C.; Chelli, Mario; Rovero, Paolo; Papini, Anna M. (2002-03-01). "Assessment of new 6-Cl-HOBt based coupling reagents for peptide synthesis. Part 1: Coupling efficiency study" (in en). Letters in Peptide Science 9 (2–3): 119–123. doi:10.1007/bf02576873. ISSN 0929-5666.
Original source: https://en.wikipedia.org/wiki/HCTU.
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