Chemistry:Jasplakinolide
Jasplakinolide is a naturally occurring cyclo-depsipeptide. It was first isolated from a species of marine sponge named Jaspis johnstoni. It is permeable to the cell membrane meaning that it is able to cross the membrane.[1] Once it crosses the cell membrane, it is a potent inducer and stabilizer of actin filaments meaning that it rapidly stabilizes pre-existing filaments and polymerize the protein actin.[2] It also inhibits the disassembly of theses filaments. When doing this, it competes with phalloidin making it unable to bind with F-actin.[3]
Applications
Jasplakinolide is potentially important in medical applications showing anti-cancer, fungicidal and antiproliferative properties. It also has important scientific applications for the study of organelles, and actin filaments.[1][2][4]
References
- ↑ 1.0 1.1 Holzinger, Andreas (2009). "Jasplakinolide: an actin-specific reagent that promotes actin polymerization". Cytoskeleton Methods and Protocols. Methods in Molecular Biology (Clifton, N.J.). 586. pp. 71–87. doi:10.1007/978-1-60761-376-3_4. ISBN 978-1-60761-375-6.
- ↑ 2.0 2.1 Bubb, Michael R.; Spector, Ilan; Beyer, Bret B.; Fosen, Katina M. (2000-02-18). "Effects of Jasplakinolide on the Kinetics of Actin Polymerization: AN EXPLANATION FOR CERTAIN IN VIVO OBSERVATIONS*". Journal of Biological Chemistry 275 (7): 5163–5170. doi:10.1074/jbc.275.7.5163. ISSN 0021-9258. PMID 10671562.
- ↑ "Jasplakinolide | Actin Polymerization Inducer | MedChemExpress". https://www.medchemexpress.com/jasplakinolide.html.
- ↑ Bubb, M. R.; Senderowicz, A. M.; Sausville, E. A.; Duncan, K. L.; Korn, E. D. (1994-05-27). "Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.". Journal of Biological Chemistry 269 (21): 14869–14871. doi:10.1016/S0021-9258(17)36545-6. ISSN 0021-9258. PMID 8195116.
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