Chemistry:McCormack reaction
From HandWiki
The McCormack reaction is a method for the synthesis of organophosphorus compounds. In this reaction, a 1,3-diene and a source of R2P+ are combined to give phospholenium cation. The reaction is named after W. B. McCormack, a research chemist at duPont. An illustrative reaction involves phenyldichlorophosphine and isoprene:[1]
The reaction proceeds via a pericyclic [2+4]-process. The resulting derivatives can be hydrolyzed to give the phosphine oxide. Dehydrohalogenation gives the phosphole.[2]
References
- ↑ W. B. McCormack (1973). "3-Methyl-1-Phenylphospholene oxide". Organic Syntheses. http://www.orgsyn.org/demo.aspx?prep=CV5P0787.; Collective Volume, 5, pp. 787
- ↑ Handbook of organophosphorus chemistry by Robert Engel, CRC Press, 1992. ISBN:0-8247-8733-1.
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