Chemistry:Miniprotein
From HandWiki
Short description: Long peptide with tertiary structure
A miniprotein is a type of peptide, characterized by the presence of protein tertiary structure.[1] In nature, they are commonly found in the venom of animals[2] such as scorpions,[3] spiders,[4] and cone snails.[5] It is also possible to create miniproteins de novo using protein design.[6]
References
- ↑ "Miniproteins as a Powerful Modality in Drug Development". Trends Biochem Sci 45 (4): 332–346. 2021. doi:10.1016/j.tibs.2019.12.008. PMID 32014389.
- ↑ "Therapeutic potential of venom peptides". Nat Rev Drug Discov 2 (10): 790–802. 2003. doi:10.1038/nrd1197. PMID 14526382. Bibcode: 2003NRvDD...2..790L.
- ↑ "Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers". Pharmacol Res 197 (106978). 2023. doi:10.1016/j.phrs.2023.106978. PMID 37923027.
- ↑ "Spider Venom: Components, Modes of Action, and Novel Strategies in Transcriptomic and Proteomic Analyses". Toxins 11 (10): 611. 2019. doi:10.3390/toxins11100611. PMID 31652611.
- ↑ "Conotoxins: Classification, Prediction, and Future Directions in Bioinformatics". Toxins 17 (2): 78. 2025. doi:10.3390/toxins17020078. PMID 39998095.
- ↑ "Accurate de novo design of hyperstable constrained peptides". Nature 538 (7625): 329–335. 2016. doi:10.1038/nature19791. PMID 27626386. Bibcode: 2016Natur.538..329B.
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