Chemistry:Myricanol
From HandWiki
Myricanol, is a natural product which acts as an activator of the enzymes nicotinamide phosphoribosyltransferase (NAMPT)[1] and SIRT1,[2][3] along with various other activities. It is derived from the ayurvedic medicinal plant Myrica nagi and other related species along with other similar compounds such as myricetin.[4][5][6]
It has hepatoprotective,[4] reno-protective[7] neuroprotective[8] and anti-cancer properties[9] in experimental models, and lowers levels of microtubule-associated protein tau.[10][11]
References
- ↑ "Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator". Bioorganic Chemistry 133. April 2023. doi:10.1016/j.bioorg.2023.106435. PMID 36841049.
- ↑ "Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism". Journal of Cachexia, Sarcopenia and Muscle 10 (2): 429–444. April 2019. doi:10.1002/jcsm.12393. PMID 30793539.
- ↑ "Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice". Biomedicine & Pharmacotherapy 174. May 2024. doi:10.1016/j.biopha.2024.116557. PMID 38583337.
- ↑ 4.0 4.1 "[Protective effects of the bark of Myrica rubra Sieb. et Zucc. on experimental liver injuries]". Yakugaku Zasshi 112 (4): 244–252. April 1992. doi:10.1248/yakushi1947.112.4_244. PMID 1403657.
- ↑ "Bioactive constituents of Chinese natural medicines. VII. Inhibitors of degranulation in RBL-2H3 cells and absolute stereostructures of three new diarylheptanoid glycosides from the bark of Myrica rubra". Chemical & Pharmaceutical Bulletin 50 (2): 208–215. February 2002. doi:10.1248/cpb.50.208. PMID 11848211.
- ↑ "Convergent total synthesis of (±) myricanol, a cyclic natural diarylheptanoid". Organic & Biomolecular Chemistry 16 (45): 8859–8869. November 2018. doi:10.1039/c8ob02052c. PMID 30411771.
- ↑ "Myricanol represses renal fibrosis by activating TFAM and ZNRF1 to inhibit tubular epithelial cells ferroptosis". European Journal of Pharmacology 984. December 2024. doi:10.1016/j.ejphar.2024.176999. PMID 39349116.
- ↑ "Study on the Material Basis of Neuroprotection of Myrica rubra Bark". Molecules 24 (16): 2993. August 2019. doi:10.3390/molecules24162993. PMID 31426594.
- ↑ "Myricanol induces apoptotic cell death and anti-tumor activity in non-small cell lung carcinoma in vivo". International Journal of Molecular Sciences 16 (2): 2717–2731. January 2015. doi:10.3390/ijms16022717. PMID 25629230.
- ↑ "The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau". Journal of Natural Products 74 (1): 38–44. January 2011. doi:10.1021/np100572z. PMID 21141876. Bibcode: 2011JNAtP..74...38J.
- ↑ "Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance". ACS Chemical Biology 10 (4): 1099–1109. April 2015. doi:10.1021/cb501013w. PMID 25588114.
Further reading
- "Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance". British Journal of Pharmacology 176 (20): 3983–4001. October 2019. doi:10.1111/bph.14802. PMID 31339170.
- "Myricanol Inhibits the Type III Secretion System of Salmonella enterica Serovar Typhimurium by Interfering With the DNA-Binding Activity of HilD". Frontiers in Microbiology 11. 2020. doi:10.3389/fmicb.2020.571217. PMID 33101243.
- "Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling". Frontiers in Physiology 12. 2021. doi:10.3389/fphys.2021.790345. PMID 35185599.
- "Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5". MedComm 5 (6). June 2024. doi:10.1002/mco2.566. PMID 38868327.
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