Chemistry:Pseudouridimycin

From HandWiki

Pseudouridimycin (PUM) is an experimental antibiotic isolated from the soil bacteria Streptomyces albus. It inhibits bacterial RNA polymerase through a different mechanism from previously discovered drugs. Pseudouridimycin shows useful activity against pathogens such as multidrug-resistant Streptococcus pyogenes, and while it is unclear whether it will be suitable for development for medical use in its own right, modified derivatives have been produced with improved stability and similar antibiotic properties.[1][2][3][4][5]

See also

References

  1. ↑ "Pseudouridimycin: The First Nucleoside Analogue That Selectively Inhibits Bacterial RNA Polymerase". Angewandte Chemie 56 (43): 13184–13186. October 2017. doi:10.1002/anie.201708133. PMID 28895263. Bibcode: 2017ACIE...5613184C. 
  2. ↑ "Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase". Journal of Industrial Microbiology & Biotechnology 46 (3–4): 335–343. March 2019. doi:10.1007/s10295-018-2109-2. PMID 30465105. 
  3. ↑ "Total Synthesis of Pseudouridimycin". Organic Letters 24 (2): 511–515. January 2022. doi:10.1021/acs.orglett.1c03914. PMID 35005956. 
  4. ↑ "Pseudouridimycin-A Potent Nucleoside Inhibitor of the RNA Polymerase Beta Prime Subunit of Streptococcus pyogenes". ACS Omega 8 (8): 7989–8000. February 2023. doi:10.1021/acsomega.2c07805. PMID 36873015. 
  5. ↑ "Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide-Modified Analogues". ChemMedChem 19 (1). January 2024. doi:10.1002/cmdc.202300474. PMID 37751316. 



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