Chemistry:Raf kinase inhibitor protein
From HandWiki
The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell.[1] RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1-MEK1/2, ERK1/2 and NF-kappaB signalling pathways, by interaction with the Raf-1 kinase.[1] RKIP has also been shown to inhibit G protein coupled receptor kinases (GRK) when phosphorylated by protein kinase C.[2] Via this mechanism it has been shown to exert beneficial effects on cardiac structure and function.[3]
References
- ↑ 1.0 1.1 Odabaei, Golaun; Chatterjee, Devasis; Jazirehi, Ali R.; Goodglick, Lee; Yeung, Kam; Bonavida, Benjamin (2004). "Raf-1 Kinase Inhibitor Protein: Structure, Function, Regulation of Cell Signaling, and Pivotal Role in Apoptosis". in Vande Woude, George F.. Advances in Cancer Research. 91. Elsevier. pp. 169-200. doi:10.1016/S0065-230X(04)91005-6. ISBN 978-0-12-006691-9. https://archive.org/details/advancesincancer0000unse_n0p5/page/168/mode/2up.
- ↑ Lorenz, Kristina; Lohse, Martin J.; Quitterer, Ursula (4 December 2003). "Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2". Nature 426 (6966): 574–579. doi:10.1038/nature02158. EBSCOhost 11581735. ISSN 1476-4687. PMID 14654844. https://pubmed.ncbi.nlm.nih.gov/14654844/.
- ↑ Schmid, Evelyn; Neef, Stefan; Berlin, Christopher; Tomasovic, Angela; Kahlert, Katrin; Nordbeck, Peter; Deiss, Katharina; Denzinger, Sabrina et al. (19 October 2015). "Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy". Nature Medicine 21 (11): 1298–1306. doi:10.1038/nm.3972. EBSCOhost 110747403. ISSN 1546-170X. PMID 26479924. https://pubmed.ncbi.nlm.nih.gov/26479924/.
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