Chemistry:SPR741
From HandWiki
SPR741 is an experimental antibiotic related to Polymyxin B. It shows activity against a number of bacterial pathogens, especially Acinetobacter baumannii and Klebsiella pneumoniae, acting as an antibiotic adjuvant which disrupts the outer membrane of Gram-negative bacteria and allows other antibiotics to more effectively penetrate into the cell.[1][2][3][4]
References
- ↑ "Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects". Antimicrobial Agents and Chemotherapy 63 (9). September 2019. doi:10.1128/AAC.00892-19. PMID 31262767.
- ↑ "Polymyxin Derivatives that Sensitize Gram-Negative Bacteria to Other Antibiotics". Molecules 24 (2): 249. January 2019. doi:10.3390/molecules24020249. PMID 30641878.
- ↑ "SPR741, Double- or Triple-Combined With Erythromycin and Clarithromycin, Combats Drug-Resistant Klebsiella pneumoniae, Its Biofilms, and Persister Cells". Frontiers in Cellular and Infection Microbiology 12. 2022. doi:10.3389/fcimb.2022.858606. PMID 35372124.
- ↑ "Triple combination of SPR741, clarithromycin, and erythromycin against Acinetobacter baumannii and its tolerant phenotype". Journal of Applied Microbiology 134 (1). January 2023. doi:10.1093/jambio/lxac023. PMID 36626755.
 |  |
