Chemistry:Stachydrine
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Stachydrine, also known as proline betaine, is a naturally occurring alkaloid found in citrus, caper, chestnuts, alfalfa, Leonurus japonicus, Maclura tricuspidata, Stachys arvensis and Arisaema heterophyllum. It has been studied for its potential health benefits.[1][2][3] Neonatology researchers from the Masonic Institute for the Developing Brain at the University of Minnesota demonstrated that both stachydrine and the related molecule, homostachydrine, displayed lowered CSF and blood levels in Rhesus Macaques with early-life iron deficiency providing a possible diagnostic biomarker in humans.[4][5]
References
- ↑ Cheng, Fang; Zhou, Yanxi; Wang, Miao; Guo, Chuanjie; Cao, Zhixing; Zhang, Ruoqi; Peng, Cheng (2020). "A review of pharmacological and pharmacokinetic properties of stachydrine" (in en). Pharmacological Research 155. doi:10.1016/j.phrs.2020.104755. PMID 32173585.
- ↑ He, Zekun; Li, Peng; Liu, Pan; Xu, Ping (2024-08-06). "Exploring stachydrine: from natural occurrence to biological activities and metabolic pathways". Frontiers in Plant Science 15. doi:10.3389/fpls.2024.1442879. ISSN 1664-462X. PMID 39170783. Bibcode: 2024FrPS...1542879H.
- ↑ Heinzmann, Silke S; Brown, Ian J; Chan, Queenie; Bictash, Magda; Dumas, Marc-Emmanuel; Kochhar, Sunil; Stamler, Jeremiah; Holmes, Elaine et al. (2010). "Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption123". The American Journal of Clinical Nutrition 92 (2): 436–443. doi:10.3945/ajcn.2010.29672. ISSN 0002-9165. PMID 20573794.
- ↑ Sandri, Brian J; Kim, Jonathan; Lubach, Gabriele R; Lock, Eric F; Ennis-Czerniak, Kathleen; Kling, Pamela J; Georgieff, Michael K; Coe, Christopher L et al. (March 2024). "Prognostic Performance of Hematological and Serum Iron and Metabolite Indices for Detection of Early Iron Deficiency Induced Metabolic Brain Dysfunction in Infant Rhesus Monkeys" (in en). The Journal of Nutrition 154 (3): 875–885. doi:10.1016/j.tjnut.2023.10.031. PMID 38072152.
- ↑ Rao, Raghavendra B. (2024-04-08). "Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency" (in en). Nutrients 16 (7): 1092. doi:10.3390/nu16071092. ISSN 2072-6643. PMID 38613125.
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