Chemistry:Triadimefon
From HandWiki
Triadimefon is a fungicide used in agriculture to control various fungal diseases. As a seed treatment, it is used on barley, corn, cotton, oats, rye, sorghum, and wheat.[1] In fruit it is used on pineapple and banana.[1] Non-food uses include pine seedlings, Christmas trees, turf, ornamental plants, and landscaping.[1]
Pharmacology
Estrogenic effect, inhibition of aromatase activity, decrease of estrogens production and increase androgens availability.[2]
Triadimefon potently inhibited rat’s neurosteroidogenic enzymes, 5α-Red1 and 3α-HSD.[3]
Dopamine as well as serotonergic pathways are involved.[4][5]
Psychomotor stimulatory.[6] Anti-estrogen effect.[7]
References
- ↑ 1.0 1.1 1.2 "Triadimefon Reregistration Eligibility Decision (RED) and Triadimenol Tolerance Reassessment and Risk Management Decision (TRED) Fact Sheet". Environmental Protection Agency. http://www.epa.gov/oppsrrd1/REDs/factsheets/triadimefon_triadimenol_fs.htm.
- ↑ Okubo, T.; Yokoyama, Y.; Kano, K.; Soya, Y.; Kano, I. Estimation of estrogenic and antiestro-genic activities of selected pesticides by MCF-7 cell proliferation assay. Arch. Environ. Con-tam. Toxicol. 2004, 46, 445-453.
- ↑ Shen, Xiuwei; Chen, Fan; Chen, Lanlan; Su, Ying; Huang, Ping; Ge, Ren-Shan (2017). "Effects of Fungicides on Rat's Neurosteroid Synthetic Enzymes". BioMed Research Internation-al. 2017: 1–8. doi:10.1155/2017/5829756.
- ↑ Paredes-Zúñiga, Susana; Trost, Nils; De la Paz, Javiera F.; Alcayaga, Julio; Allende, Miguel L. (2019). "Behavioral effects of triadimefon in zebrafish are associated with alterations of the do-paminergic and serotonergic pathways". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 92: 118–126. doi:10.1016/j.pnpbp.2018.12.012.
- ↑ Walker, Q.David; Mailman, Richard B. (1996). "Triadimefon and Triadimenol: Effects on Mono-amine Uptake and Release". Toxicology and Applied Pharmacology. 139 (2): 227–233. doi:10.1006/taap.1996.0161.
- ↑ Crofton, K. M.; Boncek, V. M.; MacPhail, R. C. (1989). "Evidence for monoaminergic involve-ment in triadimefon-induced hyperactivity". Psychopharmacology. 97 (3): 326–330. doi:10.1007/BF00439445
- ↑ Jiang, Jinhua; Hu, Gaojie; Zhang, Changpeng; Zhao, Xueping; Wang, Qiang; Chen, Liezhong (2017). "Toxicological analysis of triadimefon on endocrine disruption and oxidative stress dur-ing rare minnow (Gobiocypris rarus) larvae development". Environmental Science and Pollution Research. 24 (34): 26681–26691. doi:10.1007/s11356-017-0317-3.
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