Chemistry:UBCS039
From HandWiki
UBCS039 is a drug which acts as a sirtuin-6 (SIRT6) activator. It was the first synthetic SIRT6 activator to be developed, and while it has comparatively lower potency compared to some newer agents, it is still widely used in research. It has antiinflammatory effects and is protective against kidney toxicity, as well as showing beneficial actions against lung and liver damage, cadmium toxicity, and arterial thrombosis.[1][2][3][4][5][6][7][8]
References
- ↑ "Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells". Cell Death & Disease 9 (10). September 2018. doi:10.1038/s41419-018-1065-0. PMID 30250025.
- ↑ "Sirtuin 6 regulates macrophage polarization to alleviate sepsis-induced acute respiratory distress syndrome via dual mechanisms dependent on and independent of autophagy". Cytotherapy 24 (2): 149–160. February 2022. doi:10.1016/j.jcyt.2021.09.001. PMID 34920961.
- ↑ "SIRT6 Activator UBCS039 Inhibits Thioacetamide-Induced Hepatic Injury In Vitro and In Vivo". Frontiers in Pharmacology 13. 2022. doi:10.3389/fphar.2022.837544. PMID 35517808.
- ↑ "Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis". Frontiers in Pharmacology 14. 2023. doi:10.3389/fphar.2023.1268708. PMID 38186648.
- ↑ "Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway". Acta Pharmacologica Sinica 45 (1): 137–149. January 2024. doi:10.1038/s41401-023-01148-w. PMID 37640899.
- ↑ "Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition". Journal of Hazardous Materials 476. September 2024. doi:10.1016/j.jhazmat.2024.135159. PMID 39002485. Bibcode: 2024JHzM..47635159Z.
- ↑ "SIRT6 mitigates acute kidney injury by enhancing lipid metabolism and reducing tubular epithelial cell apoptosis via suppression of the ACMSD signaling pathway". Cellular Signalling 131. July 2025. doi:10.1016/j.cellsig.2025.111757. PMID 40120964.
- ↑ "Cadmium exposure triggers vimentin phosphorylation via SIRT6-regulated AKT/PI3K signaling pathway in COPD". European Journal of Cell Biology 104 (3). September 2025. doi:10.1016/j.ejcb.2025.151503. PMID 40609497.
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