Chemistry:Vasopressin analogue
| Vasopressin analogue | |
|---|---|
| Drug class | |
 Vasopressin | |
| Class identifiers | |
| Use | Diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, etc. |
| ATC code | H01BA |
| Biological target | Vasopressin receptor |
Vasopressin analogues are chemicals similar in function but not necessarily similar in structure to vasopressin (ADH), such as desmopressin.
Desmopressin is administered as an oral spray to treat diseases where ADH is either not being produced in sufficient amounts, or vasopressin's receptors are not being stimulated by vasopressin. An example of desmopressin's use is for childhood bed-wetting, where it is believed that children's circadian rhythms are not synchronized with normal light-dark cycles, and consequentially the ADH surge normal children experience at night is not experienced in these children. Taking a desmopressin dose 30–45 minutes before sleeping results in concentrated urine production, and the urination reflex experienced when the bladder fills above a certain level is not triggered.
Used in the treatment of diabetes insipidus.[1] They are also used in cirrhosis patients[2]
References
- ↑ "Desmopressin Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD" (in en). https://www.webmd.com/drugs/2/drug-12128/desmopressin-oral/details.
- ↑ Myc, Lukasz A; Stine, Jonathan G; Chakrapani, Rinita; Kadl, Alexandra; Argo, Curtis K (2017-01-18). "Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort". World Journal of Hepatology 9 (2): 106–113. doi:10.4254/wjh.v9.i2.106. ISSN 1948-5182. PMID 28144392.
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