Company:CanSino Biologics

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Short description: Chinese vaccine company

[ ⚑ ] 39°04′26″N 117°32′35″E / 39.0739°N 117.5430°E / 39.0739; 117.5430

CanSino Biologics Inc.
CanSinoBIO
Native name
康希诺生物
Founded2009; 15 years ago (2009) in Tianjin, China
Founders
  • Yu Xuefeng
  • Zhu Tao
  • Qiu Dongxu
  • Helen Mao Huihua
Headquarters185 South Avenue, TEDA West District,
Tianjin
,
China
Website

CanSino Biologics (simplified Chinese: 康希诺生物; traditional Chinese: 康希諾生物; pinyin: Kāngxīnuò Shēngwù), often abbreviated as CanSinoBIO, is a Chinese vaccine company.[1]

History

CanSino Biologics was founded in 2009 in Tianjin by Yu Xuefeng, Zhu Tao, Qiu Dongxu and Helen Mao Huihua.[1]

In July 2018, it filed an application to list on the Hong Kong Stock Exchange.[1] It debuted on 28 March 2019 with an increase of 59%, the highest first day trading gain in Hong Kong since 2017.[2] In August 2020, it completed a secondary offering on Shanghai Stock Exchange's STAR market where it raised 5.2 billion yuan (US$750 million).[3]

Vaccines

The company has a portfolio of vaccines under research including Ad5-EBOV to prevent Ebola and Ad5-nCoV for COVID-19.[1][4] The company has previously collaborated with the National Research Council of Canada (NRC) on vaccine development. The two organizations began collaborating in 2013, and they later worked together to develop an Ebola vaccine.[5][6][7]

COVID-19 vaccine development

Main page: Biology:Convidecia
A multi-dose vial of CanSino's Convidecia vaccine for COVID-19 (AD5-nCOV) filled and finished in Mexico.

AD5-nCOV, trade-named Convidecia, is a single-dose[8] viral vector COVID-19 vaccine developed by CanSino. Since late 2020, it has been in Phase III trials in Chile ,[9] Mexico,[10] Pakistan ,[11] Russia ,[12] and Saudi Arabia[11] with 40,000 participants.

In February 2021, global data from Phase III trials and 101 COVID cases showed that the vaccine had a 65.7% efficacy in preventing moderate symptoms of COVID-19, and 91% efficacy in preventing severe disease.[13] It has similar efficacy to the Janssen vaccine, another one-shot adenovirus vector vaccine with 66% efficacy in a global trial.[14][8] Its single-dose regimen and normal refrigerator storage requirement make it a favorable vaccine option for many countries.[14] The vaccine is approved for emergency use listing by the WHO.[15]

In April 2021, CanSino Biologics began clinical trials for a version of its Covid-19 vaccine administered by inhalation rather than injection.[16] Rollout of inhaled boosters began in China in October 2022.[17]

Convidecia is approved for use by some countries in Asia,[18][19][20] Latin America,[21][22][23] and by Hungary.[24][25] Production capacity for Ad5-NCov should reach 500 million doses in 2021. Manufacturing will take place in China,[26] Malaysia,[20] Mexico,[27][verification needed] and Pakistan .[28]

Investors

(As of 2018) CanSino Biologics investors included Lilly Asia Ventures, Qiming Venture Partners and SDIC Fund Management.[1]

See also

  • Sinovac
  • Sinopharm

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Ng, Eric (25 July 2018). "Chinese vaccine maker CanSino faces tough IPO sell in wake of Changsheng Bio-technology scandal". South China Morning Post. https://www.scmp.com/business/article/2156867/chinese-vaccine-maker-cansino-faces-tough-ipo-sell-wake-changsheng-bio. 
  2. ↑ Low, Zoe (29 March 2019). "Ebola vaccine maker CanSino Biologics has a plan to take its life-saving treatments well beyond China's domestic market". South China Morning Post. https://www.scmp.com/business/companies/article/3003886/ebola-vaccine-maker-cansino-biologics-has-plan-take-its-life. 
  3. ↑ Ren, Daniel (13 August 2020). "Covid-19 vaccine maker CanSino soars in Star Market debut" (in en). South China Morning Post. https://www.scmp.com/business/companies/article/3097165/cansino-biologics-chinas-first-drug-maker-start-human-trials. Retrieved 15 August 2020. 
  4. ↑ Pinghui, Zhuang (10 April 2020). "Volunteers needed for second phase of China coronavirus vaccine trial". South China Morning Post (Beijing). https://www.scmp.com/news/china/society/article/3079429/volunteers-needed-second-phase-china-coronavirus-vaccine-trial. 
  5. ↑ Canada, National Research Council. "The National Research Council of Canada and CanSino Biologics Inc. announce collaboration to advance vaccine against COVID-19" (in en). www.newswire.ca. https://www.newswire.ca/news-releases/the-national-research-council-of-canada-and-cansino-biologics-inc-announce-collaboration-to-advance-vaccine-against-covid-19-816213726.html. Retrieved 19 May 2020. 
  6. ↑ "National Research Council contribution plays key role in newly approved Ebola vaccine". National Research Council Canada. March 20, 2018. https://www.newswire.ca/news-releases/national-research-council-contribution-plays-key-role-in-newly-approved-ebola-vaccine-677391803.html. "The vaccine developed by CanSino is designed to provide protection against the strain of Ebola virus that caused the 2014 outbreak." 
  7. ↑ "Canada's surprising history and questionable partnership with a Chinese company and its military-backed COVID-19 vaccine" (in en-CA). https://nationalpost.com/health/canadas-surprising-history-and-questionable-partnership-with-a-chinese-company-and-its-military-backed-covid-19-vaccine. 
  8. ↑ 8.0 8.1 "It's not just Johnson & Johnson: China has a single-dose COVID-19 vaccine that's 65% effective". https://fortune.com/2021/02/09/china-covid-vaccine-single-dose-cansino-johnson-johnson/. 
  9. ↑ "Gob.cl - Article: Science Minister: "We Work With Maximum Rigor So That Science And Technology Benefit People'S Health"". https://www.gob.cl/en/news/science-minister-we-work-with-maximum-rigor-so-that-science-and-technology-benefit-peoples-health/. 
  10. ↑ "Chinese Covid vaccine trials to be expanded to five more states". 2020-11-10. https://mexiconewsdaily.com/news/chinese-covid-vaccine-trials-to-be-expanded-to-five-more-states/. 
  11. ↑ 11.0 11.1 "Phase III Trial of A COVID-19 Vaccine of Adenovirus Vector in Adults 18 Years Old and Above - Full Text View - ClinicalTrials.gov". https://clinicaltrials.gov/ct2/show/NCT04526990. 
  12. ↑ "Russia approves clinical trials for Chinese COVID-19 vaccine Ad5-Ncov: Ifax". Reuters. 2020-12-07. https://ca.reuters.com/article/us-health-coronavirus-china-russia-idUSKBN28H0RN. 
  13. ↑ "CanSinoBIO's COVID-19 vaccine 65.7% effective in global trials, Pakistan official says". Reuters. 8 February 2021. https://www.reuters.com/article/us-health-coronavirus-vaccine-pakistan/cansinobios-covid-19-vaccine-657-effective-in-global-trials-pakistan-official-says-idUSKBN2A81N0. 
  14. ↑ 14.0 14.1 "China's CanSino Covid Vaccine Shows 65.7% Efficacy". Bloomberg.com. 2021-02-08. https://www.bloomberg.com/news/articles/2021-02-08/pakistan-says-cansino-s-covid-vaccine-shows-65-7-efficacy. 
  15. ↑ "COVID-19 Vaccines with WHO Emergency Use Listing" (in en). WHO. 3 November 2021. https://extranet.who.int/pqweb/vaccines/vaccinescovid-19-vaccine-eul-issued. 
  16. ↑ "CanSino Biologics to start clinical trials of inhaled Covid-19 vaccine" (in en-US). 2021-04-20. https://www.pharmaceutical-technology.com/news/cansino-trials-inhaled-vaccine/. 
  17. ↑ Gao, Jiaxuan (December 2022). "Vaccination with CanSinoBIO's inhaled COVID-19 vaccine has begun in China". Journal of Biosafety and Biosecurity 4 (2): 163. doi:10.1016/j.jobb.2022.12.002. PMID 36589793. 
  18. ↑ Liu, Roxanne (2021-02-25). "China approves two more domestic COVID-19 vaccines for public use". Reuters. https://www.reuters.com/article/us-health-coronavirus-china-vaccine-idUSKBN2AP1MW. 
  19. ↑ "Pakistan purchases over 30 million COVID doses from China: sources" (in en-US). 2021-04-25. https://arynews.tv/en/covid-vaccine-doses-pakistan-china-2/. 
  20. ↑ 20.0 20.1 "Malaysia to receive CanSino vaccine this month | The Malaysian Insight" (in en). https://www.themalaysianinsight.com/s/308349. 
  21. ↑ "'Our gratitude always': From China's CanSino, Mexico welcomes biggest vaccine shipment yet". Reuters. 2021-02-11. https://www.reuters.com/article/health-coronavirus-mexico-vaccine-idUKL1N2KH1H2. 
  22. ↑ "Argentina issues emergency approval to China's single-dose Cansino COVID-19 vaccine". 2021-06-11. https://www.reuters.com/world/americas/argentina-issues-emergency-approval-chinas-single-dose-cansino-covid-19-vaccine-2021-06-11/. 
  23. ↑ "ISP Approves Emergency Use And Importation Of Cansino Vaccine To Fight COVID-19". https://www.ispch.cl/noticia/isp-aprueba-uso-de-emergencia-e-importacion-de-la-vacuna-covid-19-de-laboratorio-cansino/. 
  24. ↑ Ashok, Rashmi (2021-03-22). "UPDATE 2-China's CanSino Biologics COVID-19 vaccine receives emergency use approval in Hungary". Reuters. https://www.reuters.com/article/health-coronavirus-cansinobio-hungary-idUSL1N2LK00K. 
  25. ↑ "Membrii NITAG au venit cu recomandări privind utilizarea vaccinurilor împotriva COVID-19 în Republica Moldova" (in en). 2021-03-03. https://msmps.gov.md/comunicare/comunicate/membrii-nitag-au-venit-cu-recomandari-privind-utilizarea-vaccinurilor-impotriva-covid-19-in-republica-moldova/. 
  26. ↑ "China can hit 500-mln-dose annual capacity of CanSinoBIO COVID-19 vaccine this year". 27 February 2021. https://finance.yahoo.com/news/china-hit-500-mln-dose-103509138.html. 
  27. ↑ Solomon, Daina Beth (2021-02-28). "China's CanSino says first vaccines packaged in Mexico will be ready in March". Reuters. https://www.reuters.com/article/us-health-coronavirus-mexico-vaccine-idUSKCN2AS0P0. 
  28. ↑ "Pakistan develops homemade anti-Covid vaccine 'PakVac'" (in en). 2021-05-24. http://tribune.com.pk/story/2301333/pakistan-develops-homemade-anti-covid-vaccine-pakvac. 



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