Engineering:Organ cryopreservation
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Short description: Cryopreservation of Organs
Organ cryopreservation is the cryopreservation of animals or human organs, typically around -196 °C using liquid nitrogen. At this temperature, organs can be preserved for a long period, often more than a decade.[1]
As of 2025[update], organ cryopreservation remains experimental.[2][3][4] Most organs are usually preserved at a temperature of just above 0°C, which allows them to be stored for a few hours to a few days. Certain organs may be preserved at temperatures between -20°C to -50°C, enabling storage for a few weeks to a few months. In 2023, researchers successfully cryopreserved rat kidneys at -196°C using liquid nitrogen for 100 days.[5]
See also
- Cryopreservation
- Embryo cryopreservation
- Oocyte cryopreservation
- Ovarian tissue cryopreservation
- Semen cryopreservation
- Tissue cryopreservation
References
- ↑ Chen, Jiangming; Liu, Xiangjian; Hu, Yuying; Chen, Xiaoxiao; Tan, Songwen (2023). "Cryopreservation of tissues and organs: present, bottlenecks, and future". Frontiers in Veterinary Science 10. doi:10.3389/fvets.2023.1201794. PMID 37303729.
- ↑ Ran, Qiulin; Zhang, Jiayi; Zhong, Jisheng; Lin, Ji; Zhang, Shuai; Li, Guang; You, Bin (26 March 2025). "Organ preservation: current limitations and optimization approaches". Frontiers in Medicine 12. doi:10.3389/fmed.2025.1566080. PMID 40206471.
- ↑ Khaydukova, Irina; Ivannikova, Valeria; Zhidkov, Dmitry; Belikov, Nikita; Peshkova, Maria; Timashev, Peter; Tsiganov, Dmitry; Pushkarev, Aleksandr (2024). "Current State and Challenges of Tissue and Organ Cryopreservation in Biobanking". International Journal of Molecular Sciences 25 (20). doi:10.3390/ijms252011124. PMID 39456905.
- ↑ Bakhach, Joseph (2009). "The cryopreservation of composite tissues". Organogenesis 5 (3): 119–126. doi:10.4161/org.5.3.9583. PMID 20046674.
- ↑ Han, Zonghu; Rao, Joseph; Gangwar, Lakshya; Namsrai, Bat; Allen, Jacqueline; Etheridge, Michael; Wolf, Susan; Pruett, Timothy et al. (2023). "Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model". Nature Communications 14 (1). doi:10.1038/s41467-023-38824-8. PMID 37296144. Bibcode: 2023NatCo..14.3407H.
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