From HandWiki

Although the term has occasionally been used in other ways, in medical literature biotrauma is usually defined as a severe inflammatory response produced in the lungs of patients who breathe by means of a mechanical ventilator for a long period of time.[1] The term was coined in a 1998 paper by L. N. Tremblay and A. S. Slutsky, titled Ventilator-induced injury: from barotrauma to biotrauma.[2] The message of that paper was that barotrauma caused by pressure differentials is only one of several types of lung damage that a ventilator can produce.


  1. "Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature". Neth J Med 63 (10): 382–92. 2005. PMID 16301759. 
  2. "Ventilator-induced injury: from barotrauma to biotrauma". Proc Assoc Am Physicians 110 (6): 482–8. 1998. PMID 9824530.