Medicine:COVID-19 vaccine side effects

From HandWiki

Several adverse events of COVID-19 vaccines have been reported and are being researched.

Embolic and thrombotic events

Post-vaccination embolic and thrombotic events, termed vaccine-induced immune thrombotic thrombocytopenia (VITT),[1][2][3][4][5] vaccine-induced prothrombotic immune thrombocytopenia (VIPIT),[6] thrombosis with thrombocytopenia syndrome (TTS),[7][4][5] vaccine-induced immune thrombocytopenia and thrombosis (VITT),[5] or vaccine-associated thrombotic thrombocytopenia (VATT),[5] are rare types of blood clotting syndromes that were initially observed in a number of people who had previously received the Oxford–AstraZeneca COVID‑19 vaccine (AZD1222)[lower-alpha 1] during the COVID‑19 pandemic.[6][12] It was subsequently also described in the Janssen COVID‑19 vaccine (Johnson & Johnson) leading to suspension of its use until its safety had been reassessed.[13]

Tinnitus

Main page: Medicine:Tinnitus

There have been several reports of tinnitus as a rare side effect of COVID-19 vaccines, and experts have called for more research into a possible link. The US CDC acknowledged reports of tinnitus following the administration of mRNA vaccines Pfizer and Moderna.[14][15] Other reports suggest it may be a side effect of the COVID-19 disease.[16]

See also

Notes

  1. ↑ The Oxford–AstraZeneca COVID‑19 vaccine is codenamed AZD1222,[8] and later supplied under brand names, including Vaxzevria[9] and Covishield.[10][11]

References

  1. ↑ "Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination". The New England Journal of Medicine 384 (22): 2092–101. June 2021. doi:10.1056/NEJMoa2104840. PMID 33835769. 
  2. ↑ "SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia". The New England Journal of Medicine 384 (23): 2254–2256. June 2021. doi:10.1056/NEJMe2106315. PMID 33861524. 
  3. ↑ "SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia". Thrombosis Research 209: 75–79. December 2021. doi:10.1016/j.thromres.2021.12.002. PMID 34894531. 
  4. ↑ 4.0 4.1 "Vaccine-induced immune thrombotic thrombocytopenia". The Lancet. Haematology 9 (1): e73–e80. November 2021. doi:10.1016/S2352-3026(21)00306-9. PMID 34774202. "Although initially several terms were used to describe the syndrome … the term that has gained widespread use is vaccine-induced immune thrombotic thrombocytopenia (VITT). Thrombosis with thrombocytopenia syndrome has also been used, but it is a more general term that can be caused by other conditions". 
  5. ↑ 5.0 5.1 5.2 5.3 "Editorial on Thaler et al. long-term follow-up after successful treatment of vaccine-induced prothrombotic immune thrombocytopenia. Thromb Res 2021 in press". Thrombosis Research 207: 158–160. October 2021. doi:10.1016/j.thromres.2021.10.007. PMID 34757250. "We believe the name "VITT" works well … the term clearly denotes the key features of the disorder … provides a useful mnemonic for disease recognition in the usual sequence of events … need not mandate that thrombosis be present … "TTS" … has limited clinical utility, since many conditions … present with the duad of thrombosis and thrombocytopenia". 
  6. ↑ 6.0 6.1 "Use of AstraZeneca COVID-19 vaccine in younger adults" (Press release). Health Canada. 29 March 2021. Retrieved 2 April 2021.
  7. ↑ "Thrombosis with thrombocytopenia syndrome associated with COVID-19 vaccines". The American Journal of Emergency Medicine 49: 58–61. November 2021. doi:10.1016/j.ajem.2021.05.054. PMID 34062319. 
  8. ↑ "AstraZeneca COVID-19 Vaccine (AZD1222)". AstraZeneca. 27 January 2021. https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-01/02-COVID-Villafana.pdf. 
  9. ↑ "Vaxzevria (previously COVID-19 Vaccine AstraZeneca) EPAR". https://www.ema.europa.eu/en/medicines/human/EPAR/vaxzevria-previously-covid-19-vaccine-astrazeneca. "The name of the vaccine was changed to Vaxzevria on 25 March 2021."  Vaxzevria (COVID‑19 Vaccine (ChAdOx1-S recombinant) EMA/182334/2021 Text was copied from this source which is ©️ European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  10. ↑ "ChAdOx1 nCoV- 19 Corona Virus Vaccine (Recombinant) - Covishield". https://www.seruminstitute.com/product_covishield.php. 
  11. ↑ "AstraZeneca ChAdOx1-S/nCoV-19 [recombinant, COVID-19 vaccine"]. https://www.who.int/publications/m/item/chadox1-s-recombinant-covid-19-vaccine. 
  12. ↑ "COVID-19 vaccine safety update: Vaxzevria". European Medicines Agency (EMA). 28 March 2021. https://www.ema.europa.eu/en/documents/covid-19-vaccine-safety-update/covid-19-vaccine-safety-update-vaxzevria-previously-covid-19-vaccine-astrazeneca-29-march-2021_en.pdf. 
  13. ↑ "Joint CDC and FDA Statement on Johnson & Johnson COVID-19 Vaccine". https://www.fda.gov/news-events/press-announcements/joint-cdc-and-fda-statement-johnson-johnson-covid-19-vaccine. 
  14. ↑ https://www.nbcnews.com/health/health-news/tinnitus-rare-side-effect-covid-vaccines-rcna20613
  15. ↑ https://www.medpagetoday.com/special-reports/exclusives/97592
  16. ↑ https://globalnews.ca/news/8670707/covid-19-ears-ringing-what-we-know/




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