Medicine:Cullen's sign

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Cullen's sign
Cullen's sign.jpg
Cullen's sign
SpecialtyVarious

Cullen's sign is superficial edema and bruising in the subcutaneous fatty tissue around the umbilicus.

It is named for gynecologist Thomas Stephen Cullen (1869–1953),[1] who first described the sign in ruptured ectopic pregnancy in 1916.[2]

This sign takes 24–48 hours to appear and can predict acute pancreatitis, with mortality rising from 8–10% to 40%. It may be accompanied by Grey Turner's sign[3] (bruising of the flank), which may then be indicative of pancreatic necrosis with retroperitoneal or intra-abdominal bleeding.

Causes

Causes include:

  • acute pancreatitis, where methemalbumin formed from digested blood tracks around the abdomen from the inflamed pancreas
  • bleeding from blunt abdominal trauma
  • bleeding from aortic rupture
  • bleeding from ruptured ectopic pregnancy

Importance of the sign is on a decline since better diagnostic modalities are now available.

References

  1. synd/1386 at Who Named It?
  2. T.S. Cullen. Embryology, anatomy, and diseases of the umbilicus together with diseases of the urachus. Philadelphia, Saunders, and London, 1916.
  3. "Coexistence of Cullen's and Grey Turner's signs in acute pancreatitis". Am. J. Med. 122 (4): 333–4. April 2009. doi:10.1016/j.amjmed.2008.08.032. PMID 19332225. 

External links

Classification