Medicine:Epithelial-myoepithelial carcinoma
| Epithelial-myoepithelial carcinoma | |
|---|---|
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| Micrograph of an epithelial-myoepithelial carcinoma (right of image). The epithelial component has a tubular morphology and is evident only focally (upper left of image). Benign serous glands (parotid salivary gland) are also seen (left of image). H&E stain. | |
| Specialty | ENT surgery |
Epithelial-myoepithelial carcinoma (EMCa) is a rare malignant tumour that typically arises in a salivary gland and consists of both an epithelial and myoepithelial component. They are predominantly found in the parotid gland[1] and represent approximately 1% of salivary gland tumours.[2]
Cause
Diagnosis
EMCas are diagnosed by examination of tissue, e.g. a biopsy.
This tumour is characterised by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells.
Its appearance is very similar to adenomyoepithelioma of the breast, which may be the same tumour at a different anatomical site.[3]
The histologic differential diagnosis includes adenoid cystic carcinoma and pleomorphic adenoma.
Intermed. mag.
High mag.
Prognosis
They generally have a good prognosis.[1] In one larger study, the 5-year and 10-year survival were over 90% and 80% respectively.[4]
See also
- Epithelial-myoepithelial carcinoma of the lung
- Adenomyoepithelioma
References
- ↑ 1.0 1.1 "Epithelial-myoepithelial carcinoma of the salivary gland--a low grade malignant neoplasm? Report of two cases and review of the literature". Pathology, Research and Practice 195 (3): 189–192. 1999. doi:10.1016/S0344-0338(99)80033-8. PMID 10220800.
- ↑ "Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature". Anticancer Research 18 (1B): 603–608. 1998. PMID 9568184.
- ↑ "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?". Virchows Archiv 433 (3): 285–288. September 1998. doi:10.1007/s004280050249. PMID 9769134.
- ↑ "Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract". The American Journal of Surgical Pathology 31 (1): 44–57. January 2007. doi:10.1097/01.pas.0000213314.74423.d8. PMID 17197918.
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