Medicine:Neoehrlichiosis
| Neoehrlichiosis | |
|---|---|
| Specialty | Infectious disease |
Neoehrlichiosis is a disease caused by the intracellular pathogen Neoehrlichia mikurensis. It usually presents with symptoms such as fever and vascular complications of unclear origin, e.g., thromboembolisms.[1][2]
The disease is diagnosed using a Neoehrlichia mikurensis-specific PCR.[3] Because Neoehrlichia mikurensis is an intracellular bacteria, cultivation on cell-free media and other routine microbiological methods can not be utilised for detection. This difficulty, along with being a relatively unknown disease, leads to many cases going undiagnosed for months or years, or even unrecognised entirely.[4]
Previously, it was believed that neoehrlichiosis only affected immunocompromised patients,[3] but more recent studies indicate that otherwise healthy individuals may also be susceptible.[2][5][6][7]
References
- ↑ Wennerås, C. (2015-05-11). "Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis" (in en). Clinical Microbiology and Infection 21 (7): 621–630. doi:10.1016/j.cmi.2015.02.030. PMID 25770773.
- ↑ 2.0 2.1 Höper, Linnea; Skoog, Elisabet; Stenson, Martin; Grankvist, Anna; Wass, Linda; Olsen, Björn; Nilsson, Kenneth; Mårtensson, Andreas et al. (2021-10-05). "Vasculitis due to Candidatus Neoehrlichia mikurensis: A Cohort Study of 40 Swedish Patients" (in en). Clinical Infectious Diseases 73 (7): e2372–e2378. doi:10.1093/cid/ciaa1217. ISSN 1058-4838. PMID 32818961. https://academic.oup.com/cid/article/73/7/e2372/5895073.
- ↑ 3.0 3.1 Grankvist, A.; Andersson, P.-O.; Mattsson, M.; Sender, M.; Vaht, K.; Hoper, L.; Sakiniene, E.; Trysberg, E. et al. (2014-06-15). "Infections With the Tick-Borne Bacterium "Candidatus Neoehrlichia mikurensis" Mimic Noninfectious Conditions in Patients With B Cell Malignancies or Autoimmune Diseases" (in en). Clinical Infectious Diseases 58 (12): 1716–1722. doi:10.1093/cid/ciu189. ISSN 1058-4838. PMID 24647019.
- ↑ Wass, Linda; Grankvist, Anna; Bell-Sakyi, Lesley; Bergström, Malin; Ulfhammer, Erik; Lingblom, Christine; Wennerås, Christine (2019-01-01). "Cultivation of the causative agent of human neoehrlichiosis from clinical isolates identifies vascular endothelium as a target of infection" (in en). Emerging Microbes & Infections 8 (1): 413–425. doi:10.1080/22221751.2019.1584017. ISSN 2222-1751. PMID 30898074.
- ↑ Quarsten, H.; Grankvist, A.; Høyvoll, L.; Myre, I.B.; Skarpaas, T.; Kjelland, V.; Wenneras, C.; Noraas, S. (August 2017). "Candidatus Neoehrlichia mikurensis and Borrelia burgdorferi sensu lato detected in the blood of Norwegian patients with erythema migrans" (in en). Ticks and Tick-borne Diseases 8 (5): 715–720. doi:10.1016/j.ttbdis.2017.05.004. PMID 28539197. https://linkinghub.elsevier.com/retrieve/pii/S1877959X17300341.
- ↑ Li, Hao; Jiang, Jia-Fu; Liu, Wei; Zheng, Yuan-Chun; Huo, Qiu-Bo; Tang, Kun; Zuo, Shuang-Yan; Liu, Kun et al. (October 2012). "Human Infection with Candidatus Neoehrlichia mikurensis, China". Emerging Infectious Diseases 18 (10): 1636–1639. doi:10.3201/eid1810.120594. ISSN 1080-6040. PMID 23017728. PMC 3471638. http://wwwnc.cdc.gov/eid/article/18/10/12-0594_article.htm.
- ↑ Welc-Falęciak, Renata; Siński, Edward; Kowalec, Maciej; Zajkowska, Joanna; Pancewicz, Sławomir A. (2014-07-17). Gilligan, P. H.. ed. "Asymptomatic "Candidatus Neoehrlichia mikurensis" Infections in Immunocompetent Humans" (in en). Journal of Clinical Microbiology 52 (8): 3072–3074. doi:10.1128/JCM.00741-14. ISSN 0095-1137. PMID 24899023.
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