Medicine:PhenX Toolkit

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The PhenX Toolkit
Type of site
Content Site
Available inEnglish
OwnerNHGRI
Created byRTI International
Websitewww.phenxtoolkit.org
Commercialno
RegistrationOptional
Users3700+ Registered, 1.6M+ visits
Launched6 February 2009 (2009-02-06)
Current statusActive
Content license
Public Domain

The PhenX Toolkit is a web-based catalog of high-priority measures related to complex diseases, phenotypic traits and environmental exposures. These measures were selected by working groups of experts using a consensus process.[1] PhenX Toolkit's mission is to provide investigators with standard measurement protocols for use in genomic, epidemiologic, clinical and translational research. Use of PhenX measures facilitates combining data from a variety of studies, and makes it easy for investigators to expand a study design beyond the primary research focus.[2][3][4] The Toolkit is funded by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) with co-funding by the Office of the Director (OD), the National Institute of Neurological Disorders and Stroke (NINDS), and the National Heart, Lung, and Blood Institute (NHLBI).[5][6] Continuously funded since 2007, PhenX has received funding from a variety of NIH institutes, including the National Institute on Drug Abuse (NIDA), the National Institute on Mental Health (NIMH), the National Cancer Institute (NCI) and the National Institute on Minority Health and Health Disparities (NIMHD).[7][8] The PhenX Toolkit is available to the scientific community at no cost.

For genome-wide association studies (GWAS) and other studies involving human subjects, the use of standard measures can facilitate cross-study analyses.[9][10][11] Such analyses compare independent findings to validate results or combine studies to increase sample size and statistical power.[12][13] This increased power makes it possible to identify more subtle and complex associations such as gene-gene and gene-environment interactions.[14][15][16][17] PhenX is an NIH Common Data Element (CDE) Repository project and supports the NIH Strategic Plan for Data Science, which promotes FAIR principles (i.e., Findable, Accessible, Interoperable, Reusable) to facilitate data sharing.[18]

In 2020, PhenX collaborated with the U.S. NIH's Public Health Emergency and Disaster Research Response Program (DR2) to collect and review research protocols for epidemiologists, clinicians and other scientists studying COVID-19.[19] The Toolkit released six specialty collections of protocols to promote the use of CDEs for research on COVID-19 in October 2020.[20]

See also

References

  1. ↑ Template:Cite tech report
  2. ↑ Hamilton, Carol M.; Strader, Lisa C.; Pratt, Joseph G. et al. (1 August 2011). "The PhenX Toolkit: Get the Most From Your Measures". American Journal of Epidemiology 174 (3): 253–260. doi:10.1093/aje/kwr193. PMID 21749974. 
  3. ↑ Hendershot, Tabitha; Pan, Huaqin; Haines, Jonathan et al. (October 2011). "Using the PhenX Toolkit to Add Standard Measures to Your Study". Current Protocols in Human Genetics 1 (21): Unit 1.21. doi:10.1002/0471142905.hg0121s71. PMID 21975939. 
  4. ↑ Fortier, Isabel; Doiron, Dany; Burton, Paul; Raina, Parminder (2011-08-01). "Invited Commentary: Consolidating Data Harmonization—How to Obtain Quality and Applicability?". American Journal of Epidemiology 174 (3): 261–264. doi:10.1093/aje/kwr194. ISSN 0002-9262. PMID 21749975. 
  5. ↑ RTI (January 30, 2023). "RTI's PhenX Toolkit to be established as biomedical knowledgebase with latest award". RTI International. https://www.rti.org/announcements/phenx-toolkit-be-established-biomedical-knowledgebase-latest-award?utm_source=twitter&utm_medium=social_organic&utm_campaign=SSES_NIH_ALLPhenXToolkitAnnouncementRenewal. Retrieved 10 February 2023. 
  6. ↑ "Resource Summaries" (in en). https://wayback.archive-it.org/org-350/20200602040902/https:/www.nlm.nih.gov/cde/summaries.html#PhenX. 
  7. ↑ Eckman, JR (December 26, 2017). "Standard measures for sickle cell disease research: the PhenX Toolkit sickle cell disease collections". Blood Advances 1 (27): 2703–2711. doi:10.1182/bloodadvances.2017010702. PMID 29296922. PMC 5745137. http://www.bloodadvances.org/content/bloodoa/1/27/2703.full.pdf?sso-checked=true. Retrieved 9 May 2018. 
  8. ↑ "The PhenX Toolkit" (in en). 2021-12-15. https://www.rti.org/impact/phenx-toolkit. 
  9. ↑ Pan, Huaqin; Tryka, Kimberly A.; Vreeman, Daniel J. et al. (May 2012). "Using PhenX Measures to Identify Opportunities for Cross-Study Analysis". Human Mutation 33 (5): 849–857. doi:10.1002/humu.22074. PMID 22415805. 
  10. ↑ Manolio, Teri A. (February 2009). "Collaborative Genome-wide Association Studies of Diverse Diseases: Programs of the NHGRI's Office of Population Genomics". Pharmacogenomics 10 (3): 235–241. doi:10.2217/14622416.10.2.235. PMID 19207024. 
  11. ↑ Sheehan, Jerry; Hirschfeld, Steven; Foster, Erin; Ghitza, Udi; Goetz, Kerry; Karpinski, Joanna; Lang, Lisa; Moser, Richard P. et al. (December 2016). "Improving the value of clinical research through the use of Common Data Elements (CDEs)". Clinical Trials (London, England) 13 (6): 671–676. doi:10.1177/1740774516653238. ISSN 1740-7745. PMID 27311638. 
  12. ↑ Sheehan, Jerry; Hirschfeld, Steven; Foster, Erin; Ghitza, Udi; Goetz, Kerry; Karpinski, Joanna; Lang, Lisa; Moser, Richard P. et al. (December 2016). "Improving the value of clinical research through the use of Common Data Elements (CDEs)". Clinical Trials (London, England) 13 (6): 671–676. doi:10.1177/1740774516653238. ISSN 1740-7745. PMID 27311638. 
  13. ↑ Fortier, Isabel; Dragieva, Nataliya; Saliba, Matilda; Craig, Camille; Robson, Paula J. (2019-04-16). "Harmonization of the Health and Risk Factor Questionnaire data of the Canadian Partnership for Tomorrow Project: a descriptive analysis". CMAJ Open 7 (2): E272–E282. doi:10.9778/cmajo.20180062. ISSN 2291-0026. PMID 31018973. 
  14. ↑ Barrett, Jeffrey C.; Hansoul, Sarah; Nicolae, Dan L. et al. (August 2008). "Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease". Nature Genetics 40 (8): 955–962. doi:10.1038/ng.175. PMID 18587394. 
  15. ↑ Barrett, Jeffrey C.; Clayton, David G.; Concannon, Patrick et al. (June 2009). "Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes". Nature Genetics 41 (6): 703–707. doi:10.1038/ng.381. PMID 19430480. PMC 2889014. http://www.zora.uzh.ch/30808/2/30808_V.pdf. 
  16. ↑ Cooper, Jason D.; Smyth, Deborah J.; Smiles, Adam M. et al. (December 2008). "Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci". Nature Genetics 40 (12): 1399–1401. doi:10.1038/ng.249. PMID 18978792. 
  17. ↑ Hunter, David J. (April 2005). "Gene-environment Interactions in Human Diseases". Nature Reviews Genetics 6 (4): 287–298. doi:10.1038/nrg1578. PMID 15803198. 
  18. ↑ "NIH Common Data Elements (CDE) Repository". https://cde.nlm.nih.gov/form/search?selectedOrg=PhenX. 
  19. ↑ "Covid-19 researchers gain quick access to surveys, protocols (Environmental Factor, May 2020)" (in en). https://factor.niehs.nih.gov/2020/5/science-highlights/protocols/index.htm. 
  20. ↑ Krzyzanowski, Michelle C.; Terry, Ian; Williams, David; West, Pat; Gridley, Lauren N.; Hamilton, Carol M. (2021). "The PhenX Toolkit: Establishing Standard Measures for COVID-19 Research" (in en). Current Protocols 1 (4): e111. doi:10.1002/cpz1.111. ISSN 2691-1299. PMID 33905618. 

External links

  • [1] dbGaP
  • [2] NIH Common Data Elements (CDE) Repository



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