Medicine:Psammoma body
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Micrograph of psammoma body in the centre of the field in a meningioma of brain. H&E stain.
A psammoma body is a round collection of calcium, seen microscopically. The term is derived from the Greek word ψάμμος (psámmos), meaning "sand".
Cause
Psammoma bodies are associated with the papillary (nipple-like) histomorphology and are thought to arise from,
- Infarction and calcification of papillae tips.
- Calcification of intralymphatic tumor thrombi.[1]
Association with lesions
Psammoma bodies are commonly seen in certain tumors such as:
- Papillary thyroid carcinoma[2]
- Papillary renal cell carcinoma[3]
- Ovarian papillary serous cystadenoma and cystadenocarcinoma[4]
- Endometrial adenocarcinomas (Papillary serous carcinoma ~3%-4%)
- Meningiomas, in the central nervous system[5]
- Peritoneal and Pleural Mesothelioma
- Somatostatinoma (pancreas)[6]
- Prolactinoma of the pituitary [7]
- Glucagonoma[8]
- Micropapillary subtype of Lung Adenocarcinoma[9]
Benign lesions
Micrograph of a psammomatous melanotic schwannoma with a psammoma body, as may be seen in Carney complex. H&E stain.
Psammoma bodies may be seen in:
Appearance
Psammoma bodies usually have a laminar appearance, are circular, acellular and basophilic.
References
- ↑ "The origin and significance of thyroid psammoma bodies". Lab. Invest. 43 (3): 287–96. September 1980. PMID 7401638.
- ↑ Chapter 20 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K; Fausto, Nelson (2007). Robbins Basic Pathology. Philadelphia: Saunders. ISBN 978-1-4160-2973-1. 8th edition.
- ↑ "Renal Cell Carcinoma". https://www.lecturio.com/concepts/renal-cell-carcinoma/.
- ↑ Ovarian papillary serous cystadenocarcinoma at WebPath, The Internet Pathology Laboratory for Medical Education at Mercer University School of Medicine. Retrieved July 2011
- ↑ "Brain Stem & Posterior Fossa". http://spinwarp.ucsd.edu/neuroweb/Text/br-300b.htm.
- ↑ Lewis RB (2010). "Pancreatic Endocrine Tumors: Radiologic-Clinicopathologic Correlation". RadioGraphics 30 (6): 1445–1464. doi:10.1148/rg.306105523. PMID 21071369.
- ↑ Robbin's Pathology, Eight Ed
- ↑ "Glucagonoma". https://www.lecturio.com/concepts/glucagonoma/.
- ↑ Emoto K, Eguchi T, Tan KS, Takahashi Y, Aly RG, Rekhtman N, Travis WD, Adusumilli PS (2019). "Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas". J Thorac Oncol 14 (11): 1948–1961. doi:10.1016/j.jtho.2019.07.008. PMID 31352072.
- ↑ "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med 36 (9): 675–8. September 1991. PMID 1774734.
- ↑ Rapini, Ronald. Practical Dermatopathology. Elsevier Mosby, 2005, p. 10.
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