Medicine:Sticky platelet syndrome
| Sticky platelet syndrome | |
|---|---|
| Specialty | Hematology |
Sticky platelet syndrome (SPS) is a heritable disorder of platelet function in which platelet hyperaggregation leads to hypercoagulability.[1][2][3][4][5] It was first described by Mammen in 1983.[6] It is inherited in an autosomal dominant pattern.[7] It has not been associated with a specific gene, and it is not recognized as an entity in OMIM.
It can present in conjunction with protein S deficiency and factor V Leiden.[8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder.
SPS has not been widely studied[9] and is not widely known.[10]
Signs and symptoms
Symptoms are related to hypercoagulability,[9] usually presenting as venous thromboembolisms, arterial thrombosis,[9] myocardial infarction, angina, and stroke.[1]
Cause
The syndrome is believed to be hereditary.[11]
Diagnosis
SPS is diagnosed by demonstrating platelet hyperaggregability. In a lab test called aggregometry, platelet stickiness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP).[12] This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system.[citation needed]
Treatment
Treatment usually consists of a daily low dose (80–100 mg) of aspirin.[13] Anticoagulants (e.g. warfarin) or antiplatelets (clopidogrel) are often additionally prescribed following formation of a medically significant clot. Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy.[citation needed]
References
- ↑ 1.0 1.1 "Sticky platelet syndrome". Seminars in Thrombosis and Hemostasis 25 (4): 361–365. 1999. doi:10.1055/s-2007-994939. PMID 10548069.
- ↑ "Sticky platelet syndrome and thrombocythemia". Hematology/Oncology Clinics of North America 17 (1): 63–83. February 2003. doi:10.1016/S0889-8588(02)00096-5. PMID 12627663.
- ↑ "Bilateral simultaneous anterior ischaemic optic neuropathy associated with Sticky Platelet Syndrome". The British Journal of Ophthalmology 93 (7): 885–6, 913. July 2009. doi:10.1136/bjo.2008.142919. PMID 18662911.
- ↑ ""Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis?". Folia Haematologica 115 (3): 361–365. 1988. PMID 2465231.
- ↑ "Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients". American Journal of Transplantation 7 (7): 1865–1868. July 2007. doi:10.1111/j.1600-6143.2007.01835.x. PMID 17532753.
- ↑ Hematological complications in obstetrics, pregnancy, and gynecology. Cambridge, UK: Cambridge University Press. 2006. pp. 147. ISBN 978-0-521-83953-2.
- ↑ Obstetric anesthesia and uncommon disorders. Cambridge, UK: Cambridge University Press. 2008. pp. 308. ISBN 978-0-521-87082-5.
- ↑ "Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes". Cerebrovascular Diseases 9 (2): 127–130. 1999. doi:10.1159/000015911. PMID 9973658.
- ↑ 9.0 9.1 9.2 "A new decade awaits sticky platelet syndrome: where are we now, how do we manage and what are the complications?". Expert Review of Hematology 15 (1): 53–63. January 2022. doi:10.1080/17474086.2022.2030217. PMID 35034520.
- ↑ "Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss". Case Reports in Nephrology 2018: 3174897. 2018. doi:10.1155/2018/3174897. PMID 29850310.
- ↑ "Hereditary and acquired thrombophilic disorders". Clinical and Applied Thrombosis/Hemostasis 12 (2): 125–135. April 2006. doi:10.1177/107602960601200201. PMID 16708115.
- ↑ "Enhanced platelet aggregation with TRAP-6 and collagen in platelet aggregometry in patients with venous thromboembolism". Thrombosis Research 107 (6): 325–328. September 2002. doi:10.1016/S0049-3848(02)00351-1. PMID 12565719.
- ↑ "Sticky platelet syndrome". Seminars in Thrombosis and Hemostasis 25 (4): 361–365. 1999. doi:10.1055/s-2007-994939. PMID 10548069.
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