Medicine:Sudden cardiac death of athletes
It remains a difficult medical challenge to prevent the sudden cardiac death of athletes, typically defined as natural, unexpected death from cardiac arrest within one hour of the onset of collapse symptoms, excluding additional time on mechanical life support.[1] (Wider definitions of sudden death are also in use, but not usually applied to the athletic situation.) Most causes relate to congenital or acquired cardiovascular disease with no symptoms noted before the fatal event. The prevalence of any single, associated condition is low, probably less than 0.3% of the population in the athletes' age group,[citation needed] and the sensitivity and specificity of common screening tests leave much to be desired. The single most important predictor is fainting or near-fainting during exercise, which should require detailed explanation and investigation.[2] The victims include many well-known names, especially in professional soccer, and close relatives are often at risk for similar cardiac problems.
Causes
The sudden cardiac deaths of 387 young American athletes (under age 35) were analyzed in a 2003 medical review:[3]
| Cause | Incidence | |
|---|---|---|
| Hypertrophic cardiomyopathy | 26% | Genetically determined |
| Commotio cordis | 20% | Structurally normal heart, disrupted electrically by a blow to the chest |
| Coronary artery anomalies | 14% | Exact mechanisms unknown; some association with other congenital CVS abnormalities |
| Left ventricular hypertrophy of undetermined origin | 7% | Probable variant of hypertrophic cardiomyopathy |
| Myocarditis | 5% | Acute inflammation |
| Ruptured aortic aneurysm (Marfan syndrome) | 3% | Genetically determined; also associated with unusual height |
| Arrhythmogenic right ventricular cardiomyopathy | 3% | Genetically determined |
| Tunneled coronary artery | 3% | Congenital abnormality |
| Aortic valve stenosis | 3% | Multiple causes |
| Atherosclerotic coronary artery disease | 3% | Mainly acquired; dominant cause in older adults |
| Other diagnosis | 13% |
While most causes of sudden cardiac death relate to congenital or acquired cardiovascular disease, an exception is commotio cordis, in which the heart is structurally normal but a potentially fatal loss of rhythm occurs because of the accident of timing of a blow to the chest. Its fatality rate is about 65% even with prompt CPR and defibrillation, and more than 80% without.[4][5]
Age 35 serves as an approximate borderline for the likely cause of sudden cardiac death. Before age 35, congenital abnormalities of the heart and blood vessels predominate. These are usually asymptomatic prior to the fatal event, although not invariably so.[6] Congenital cardiovascular deaths are reported to occur disproportionately in African-American athletes.[7]
After age 35, acquired coronary artery disease predominates (80%),[6] and this is true regardless of the athlete's former level of fitness.[citation needed]
Various performance-enhancing drugs can increase cardiac risk, though evidence has been inconclusive about their involvement in sudden cardiac deaths.[8]
Genetics
Cardiomyopathies
Cardiomyopathies are generally inherited as autosomal dominants, although recessive forms have been described, and dilated cardiomyopathy can also be inherited in an X-linked pattern. Consequently, in addition to tragedy involving an athlete who succumbs, there are medical implications for close relatives. Among family members of index cases, more than 300 causative mutations have been identified. However, not all mutations have the same potential for severe outcomes, and there is not yet a clear understanding of how these mutations (which affect the same myosin protein molecule) can lead to the dramatically different clinical characteristics and outcomes associated with hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM).[9]
Since HCM, as an example, is typically an autosomal dominant trait, each child of an HCM parent has a 50% chance of inheriting the mutation. In individuals without a family history, the most common cause of the disease is a "de novo" mutation of the gene that produces the β-myosin heavy chain.[citation needed]
Channelopathies
Sudden cardiac death can usually be attributed to cardiovascular disease or commotio cordis, but about 20% of cases show no obvious cause and remain undiagnosed after autopsy. Interest in these "autopsy-negative" deaths has centered around the "ion channelopathies". These electrolyte channels are pores regulating the movement of sodium, potassium and calcium ions into cardiac cells, collectively responsible for creating and controlling the electrical signals that govern the heart's rhythm. Abnormalities in this system occur in relatively rare genetic diseases such as Long QT syndrome, Brugada syndrome, and Catecholaminergic polymorphic ventricular tachycardia, all associated with sudden death. Consequently, autopsy-negative sudden cardiac deaths (no physical abnormalities identified) may comprise a larger part of the channelopathies than previously anticipated.[10][11]
Heritable connective tissue diseases
Heritable connective tissue diseases are rare, each disorder estimated at one to ten per 100,000, of which Marfan syndrome is the most common. It is carried by the FBN1 gene on chromosome 15, which encodes the connective protein fibrillin-1,[12][13] inherited as a dominant trait. This protein is essential for synthesis and maintenance of elastic fibers. Since these fibers are particularly abundant in the aorta, ligaments, and the ciliary zonules of the eye, these areas are among the worst affected. Everyone has a pair of FBN1 genes and, because transmission is dominant, those who have inherited one affected FBN1 gene from either parent will have Marfan syndrome. Although it is most frequently inherited as an autosomal dominant, there is no family history in 25% of cases.[14]
Recruiting practices aimed at attracting athletes who are unusually tall or who have an unusually wide arm span (characteristics of Marfan syndrome) can increase the prevalence of the syndrome within sports such as basketball and volleyball.[15]
DNA testing
After a disease-causing mutation has been identified in an index case (which is not always accomplished conclusively), the main task is genetic identification of carriers within a pedigree, a sequential process known as "cascade testing". Family members with the same mutation may show different severities of disease, a phenomenon known as "variable penetrance". As a result, some may remain asymptomatic, with little lifelong evidence of disease. Nevertheless, their children remain at risk of inheriting the disorder and potentially being more severely affected.[16]
Screening
Screening athletes for cardiac disease can be problematic because of low prevalence and inconclusive performance of various tests that have been used. Nevertheless, sudden death among seemingly healthy individuals attracts much public and legislator attention because of its visible and tragic nature.[17]
As an example, the Texas Legislature appropriated US$1 million for a pilot study of statewide athlete screening in 2007. The study employed a combination of questionnaire, examination and electrocardiography for 2,506 student athletes, followed by echocardiography for 2,051 of them, including any students with abnormal findings from the first three steps. The questionnaire alone flagged 35% of the students as potentially at risk, but there were many false positive results, with actual disease being confirmed in less than 2%. Further, a substantial number of screen-positive students declined repeated recommendations for follow-up evaluation. (Individuals who are conclusively diagnosed with cardiac disease are usually told to avoid competitive sports.) It should be stressed that this was a single pilot program, but it was indicative of the problems associated with large-scale screening, and consistent with experience in other locations with low prevalence of sudden death in athletes.[18]
Incidence
Sudden cardiac death occurs in approximately one per 200,000 young athletes per year, usually triggered during competition or practice.[6] The victim is usually male and associated with soccer, basketball, ice hockey, or American football, reflecting the large number of athletes participating in these sustained and strenuous sports.[3] For a normally healthy age group, the risk appears to be particularly magnified in competitive basketball, with sudden cardiac death rates as high as one per 3,000 annually for male basketball players in NCAA Division I.[19] This is still far below the rate for the general population, estimated as one per 1,300–1,600 and dominated by the elderly.[20] However, a population as large as the United States will experience the sudden cardiac death of a competitive athlete at the average rate of one every three days, often with significant local media coverage heightening public attention.[17]
In the United States approximately 8 to 10 deaths per year can be attributed to sudden cardiac death in NCAA with overall rate of 1 per 43,000.[21][22]
Notable cases
- ↑ "Sudden death in the young: what do we know about it and how to prevent?". Circ Arrhythmia Electrophysiol 3 (1): 96–104. February 2010. doi:10.1161/CIRCEP.109.877142. PMID 20160177.
- ↑ "Syncope in the athletic patient". Prog Cardiovasc Dis 54 (5): 438–44. March 2012. doi:10.1016/j.pcad.2012.02.003. PMID 22386295.
- ↑ 3.0 3.1 Maron, Barry J. (September 11, 2003). "Sudden Death in Young Athletes". New England Journal of Medicine 349 (11): 1064–1075. doi:10.1056/NEJMra022783. PMID 12968091.
- ↑ Maron, BJ; Estes, NAM III (March 2010). "Commotio cordis". New England Journal of Medicine 362 (10): 917–927. doi:10.1056/NEJMra0910111. PMID 20220186.
- ↑ "Position Statement on Commotio Cordis". US Lacrosse. January 2008. http://www.uslacrosse.org/safety/sudden-cardiac-arrest-aeds-commotio-cordis/position-statement-on-commotio-cordis.
- ↑ 6.0 6.1 6.2 "Sudden cardiac death athletes: a systematic review". Sports Med Arthrosc Rehabil Ther Technol 2: 19. Aug 3, 2010. doi:10.1186/1758-2555-2-19. PMID 20682064.
- ↑ "Relationship of race to sudden cardiac death in competitive athletes with hypertrophic cardiomyopathy". Journal of the American College of Cardiology 41 (6): 974–980. March 2003. doi:10.1016/S0735-1097(02)02976-5. PMID 12651044.
- ↑ La Gerche, André; Brosnan, Maria J. (January 3, 2017). "Cardiovascular Effects of Performance-Enhancing Drugs". Circulation 135 (1): 89–99. doi:10.1161/CIRCULATIONAHA.116.022535. PMID 28028062.
- ↑ "Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor". Circ Res 111 (3): 375–85. Jul 20, 2012. doi:10.1161/CIRCRESAHA.110.223842. PMID 22821910.
- ↑ "Out-of-hospital cardiac arrests: an 8-year New York City experience". Am J Emerg Med 14 (4): 364–8. Jul 1996. doi:10.1016/S0735-6757(96)90050-9. PMID 8768156.
- ↑ "Out-of-hospital cardiac arrest in the 1990s: a population-based study in the Maastricht area on incidence, characteristics and survival". J Am Coll Cardiol 30 (6): 1500–5. Nov 1997. doi:10.1016/s0735-1097(97)00355-0. PMID 9362408.
- ↑ "Mutations in the fibrillin gene responsible for dominant ectopia lentis and neonatal Marfan syndrome". Nat. Genet. 6 (1): 64–9. January 1994. doi:10.1038/ng0194-64. PMID 8136837.
- ↑ "Recent progress towards a molecular understanding of Marfan syndrome". Am J Med Genet C Semin Med Genet 139C (1): 4–9. November 2005. doi:10.1002/ajmg.c.30068. PMID 16273535.
- ↑ "Identifying heritable connective tissue disorders in childhood". Practitioner 256 (1752): 19–23, 2–3. June 2012. PMID 22916581.
- ↑ Demak, Richard (February 17, 1986). "Marfan Syndrome: A Silent Killer". Sports Illustrated. https://vault.si.com/vault/1986/02/17/marfan-syndrome-a-silent-killer. Retrieved February 12, 2021.
- ↑ "Inherited cardiomyopathies". BMJ 343: d6966. Nov 21, 2011. doi:10.1136/bmj.d6966. PMID 22106372. http://openaccess.sgul.ac.uk/110867/1/_system_appendPDF_proof_hi.pdf.
- ↑ 17.0 17.1 Link, MS; Estes, NAM III (May 2012). "Sudden Cardiac Death in the Athlete". Circulation 125 (20): 2511–2516. doi:10.1161/CIRCULATIONAHA.111.023861. PMID 22615422.
- ↑ "Lessons learned from preparticipation cardiovascular screening in a state funded program". Am J Cardiol 110 (6): 902–8. Jun 15, 2012. doi:10.1016/j.amjcard.2012.05.018. PMID 22704711.
- ↑ "Incidence of sudden cardiac death in National Collegiate Athletic Association athletes". Circulation 123 (15): 1594–1600. April 2011. doi:10.1161/CIRCULATIONAHA.110.004622. PMID 21464047.
- ↑ "Epidemiology of sudden cardiac death: clinical and research implications". Prog Cardiovasc Dis 51 (3): 213–28. Nov–Dec 2008. doi:10.1016/j.pcad.2008.06.003. PMID 19026856. "For the world (total population approx. 6,540,000,000), the estimated annual burden of sudden cardiac death would be in the range of 4–5 million cases per year.".
- ↑ Asif, Irfan M.; Harmon, Kimberly G. (2017-02-01). "Incidence and Etiology of Sudden Cardiac Death: New Updates for Athletic Departments". Sports Health 9 (3): 268–279. doi:10.1177/1941738117694153. ISSN 1941-7381. PMID 28452637.
- ↑ Harmon, Kimberly G.; Asif, Irfan M.; Maleszewski, Joseph J.; Owens, David S.; Prutkin, Jordan M.; Salerno, Jack C.; Zigman, Monica L.; Ellenbogen, Rachel et al. (2015-07-07). "Incidence, Etiology, and Comparative Frequency of Sudden Cardiac Death in NCAA Athletes: A Decade in Review". Circulation 132 (1): 10–19. doi:10.1161/CIRCULATIONAHA.115.015431. ISSN 0009-7322. PMID 25977310.
