Medicine:Transient bullous dermolysis of the newborn

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Transient bullous dermolysis of the newborn
SpecialtyDermatology

Transient bullous dermolysis of the newborn (TBDN) is a skin condition that presents in newborns. It is characterized by blister formation secondary to even mild trauma.[1]:558

A subtype of dystrophic epidermolysis bullosa,[2] it is rare, usually inherited condition that presents with characteristic blisters at birth which resolve between six months and one year of age.[3]

Blisters may cover the entire body including the mouth, and as they heal, they may leave some mild scarring. In addition, nail changes may occur which can persist to adulthood.[3]

It is associated with COL7A1.[4]

The condition was described by Ken Hashimoto in 1985.[5][6]

See also

  • Skin lesion

References

  1. ↑ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN:0-7216-2921-0.
  2. ↑ Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter et al. (2020-09-24). "Epidermolysis bullosa" (in en). Nature Reviews Disease Primers 6 (1): 78. doi:10.1038/s41572-020-0210-0. ISSN 2056-676X. PMID 32973163. https://www.nature.com/articles/s41572-020-0210-0. 
  3. ↑ 3.0 3.1 "Transient bullous dermolysis of the newborn | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program" (in en). https://rarediseases.info.nih.gov/diseases/10010/transient-bullous-dermolysis-of-the-newborn. 
  4. ↑ "Transient bullous dermolysis of the newborn associated with compound heterozygosity for recessive and dominant COL7A1 mutations". J. Invest. Dermatol. 111 (6): 1214–9. December 1998. doi:10.1046/j.1523-1747.1998.00394.x. PMID 9856844. 
  5. ↑ John Thorne Crissey; Lawrence C. Parish; Karl Holubar (2013). Historical Atlas of Dermatology and Dermatologists. CRC Press. p. 179. ISBN 978-1-84214-100-7. https://books.google.com/books?id=7ThZDwAAQBAJ&pg=PA179. 
  6. ↑ Murase, K; Kanoh, H; Ishii, N; Hashimoto, T; Nakano, H; Sawamura, D; Seishima, M (2011). "Bullous Dermolysis of the Newborn and Dystrophic Epidermolysis Bullosa Pruriginosa within the Same Family: Two Phenotypes Associated with a COL7A1 Mutation". Acta Dermato Venereologica 91 (6): 730–731. doi:10.2340/00015555-1154. ISSN 0001-5555. PMID 21629976. 

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