Physics:Gold nanobeacon

Universal gene silencing tool based on gold nanoparticles functionalized with a fluorophore labeled hairpin-DNA – Gold nanobeacon (Au-nanobeacon) – that effectively detects and silences the specific target (siRNA, miRNA or gene specific mRNA) while simultaneously signalling its action via fluorescence emission in cancer cells.

Gold nanobeacons are gold nanoparticles functionalized with a fluorophore-labelled hairpin-DNA.