View source for Biology:2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase

{{Short description|Class of enzymes}}
{{Infobox enzyme
| Name       = 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase
| EC_number  = 3.7.1.13
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase''' ({{EC number|3.7.1.13}}, ''CarC'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate acylhydrolase''.<ref>{{cite journal | vauthors = Nojiri H, Taira H, Iwata K, Morii K, Nam JW, Yoshida T, Habe H, Nakamura S, Shimizu K, Yamane H, Omori T | title = Purification and characterization of meta-cleavage compound hydrolase from a carbazole degrader Pseudomonas resinovorans strain CA10 | journal = Bioscience, Biotechnology, and Biochemistry | volume = 67 | issue = 1 | pages = 36–45 | date = January 2003 | pmid = 12619671 | doi = 10.1271/bbb.67.36 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Riddle RR, Gibbs PR, Willson RC, Benedik MJ | title = Purification and properties of 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoic acid hydrolase involved in microbial degradation of carbazole | journal = Protein Expression and Purification | volume = 28 | issue = 1 | pages = 182–9 | date = March 2003 | pmid = 12651123 | doi = 10.1016/S1046-5928(02)00676-9 }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H<sub>2</sub>O <math>\rightleftharpoons</math> anthranilate + (2E)-2-hydroxypenta-2,4-dienoate

This enzyme catalyses the third step in the aerobic degradation pathway of [[Chemistry:Carbazole|carbazole]].

== References ==
{{reflist}}

== External links ==
*{{MeshName|2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate+hydrolase}}

{{Carbon-carbon hydrolases}}
{{Enzymes}}

[[Category:EC 3.7.1]]

{{Sourceattribution|2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase}}