View source for Biology:5-HT1F receptor

{{short description|Protein-coding gene in the species Homo sapiens}}
{{DISPLAYTITLE:5-HT<sub>1F</sub> receptor}}
{{Infobox_gene}}
'''5-hydroxytryptamine (serotonin) receptor 1F''', also known as '''HTR1F'''  is a   [[Biology:5-HT1 receptor|5-HT<sub>1</sub> receptor]] [[Biology:Protein|protein]] and also denotes the human [[Biology:Gene|gene]] encoding it.<ref name="entrez">{{cite web | title = Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3355}}</ref><ref name="pmid8380639">{{cite journal | vauthors = Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA | title = Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 2 | pages = 408–12 | date = Jan 1993 | pmid = 8380639 | pmc = 45671 | doi = 10.1073/pnas.90.2.408 | bibcode = 1993PNAS...90..408A | doi-access = free }}</ref><ref name="pmid8384716">{{cite journal | vauthors = Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG | title = Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 6 | pages = 2184–8 | date = Mar 1993 | pmid = 8384716 | pmc = 46050 | doi = 10.1073/pnas.90.6.2184 | bibcode = 1993PNAS...90.2184L | doi-access = free }}</ref><ref name="pmid9394293">{{cite journal | vauthors = Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM | title = Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1) | journal = Molecular Membrane Biology | volume = 14 | issue = 3 | pages = 133–5 | year = 1997 | pmid = 9394293 | doi = 10.3109/09687689709048173 }}</ref><ref name="pmid9632173">{{cite journal | vauthors = Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR | title = Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients | journal = American Journal of Medical Genetics | volume = 77 | issue = 5 | pages = 415–20 | date = Jun 1998 | pmid = 9632173 | doi = 10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L }}</ref>

==Agonists==

* 5-''n''-Butyryloxy-DMT:<ref>{{cite journal | vauthors = Klein MT, Dukat M, Glennon RA, Teitler M | title = Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 337 | issue = 3 | pages = 860–7 | date = Jun 2011 | pmid = 21422162 | pmc = 3101003 | doi = 10.1124/jpet.111.179606 }}</ref> >60-fold selectivity versus 5-HT<sub>1E</sub> receptor
* [[Chemistry:BRL-54443|BRL-54443]] - mixed 5-HT<sub>1E/1F</sub> agonist
* [[Chemistry:Eletriptan|Eletriptan]] - mixed 5-HT<sub>1B/1D/1E/1F/2B/7</sub> agonist
* LY-334,370<ref name="pmid15900510">{{cite journal | vauthors = Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL | title = [3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties | journal = Naunyn-Schmiedeberg's Archives of Pharmacology | volume = 371 | issue = 3 | pages = 169–77 | date = Mar 2005 | pmid = 15900510 | doi = 10.1007/s00210-005-1035-9 | s2cid = 2230855 }}</ref> - as well as related [[Chemistry:Benzamide|benzamide]]s<ref name="pmid15546719">{{cite journal | vauthors = Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC | title = Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists | journal = Bioorganic & Medicinal Chemistry Letters | volume = 14 | issue = 24 | pages = 6011–6 | date = Dec 2004 | pmid = 15546719 | doi = 10.1016/j.bmcl.2004.09.079 }}</ref>
* LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
* [[Chemistry:Naratriptan|Naratriptan]] - mixed 5-HT<sub>1B/1D/1F</sub> agonist
* [[Chemistry:Lasmiditan|Lasmiditan]] - selective 5-HT<sub>1F</sub> agonist, a first-in-class [[Chemistry:Ditan|ditan]] molecule

==Antagonists==

''MLS000756415''<ref>[https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4140 PudChem: MLS000756415]</ref>

== See also ==
* [[Biology:5-HT1 receptor|5-HT<sub>1</sub> receptor]]
* [[Biology:5-HT receptor|5-HT receptor]]
{{clear}}

== References ==
{{reflist|33em}}

== Further reading ==
{{refbegin |33em}}
* {{cite journal | vauthors = Hoyer D, Hannon JP, Martin GR | title = Molecular, pharmacological and functional diversity of 5-HT receptors | journal = Pharmacology Biochemistry and Behavior | volume = 71 | issue = 4 | pages = 533–54 | date = Apr 2002 | pmid = 11888546 | doi = 10.1016/S0091-3057(01)00746-8 | s2cid = 25543069 }}
* {{cite journal | vauthors = Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN | title = Multiplicity of mechanisms of serotonin receptor signal transduction | journal = Pharmacology & Therapeutics | volume = 92 | issue = 2–3 | pages = 179–212 | year = 2002 | pmid = 11916537 | doi = 10.1016/S0163-7258(01)00169-3 }}
* {{cite journal | vauthors = Amlaiky N, Ramboz S, Boschert U, Plassat JL, Hen R | title = Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus | journal = The Journal of Biological Chemistry | volume = 267 | issue = 28 | pages = 19761–4 | date = Oct 1992 | doi = 10.1016/S0021-9258(19)88617-9 | pmid = 1328180 | doi-access = free }}
* {{cite journal | vauthors = Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA | title = Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 2 | pages = 408–12 | date = Jan 1993 | pmid = 8380639 | pmc = 45671 | doi = 10.1073/pnas.90.2.408 | bibcode = 1993PNAS...90..408A | doi-access = free }}
* {{cite journal | vauthors = Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG | title = Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 6 | pages = 2184–8 | date = Mar 1993 | pmid = 8384716 | pmc = 46050 | doi = 10.1073/pnas.90.6.2184 | bibcode = 1993PNAS...90.2184L | doi-access = free }}
* {{cite journal | vauthors = Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR | title = Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients | journal = American Journal of Medical Genetics | volume = 77 | issue = 5 | pages = 415–20 | date = Jun 1998 | pmid = 9632173 | doi = 10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L }}
* {{cite journal | vauthors = Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth B, Roth BL|author5-link=Bryan Roth | title = Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors | journal = The Journal of Biological Chemistry | volume = 279 | issue = 33 | pages = 34614–23 | date = Aug 2004 | pmid = 15190056 | doi = 10.1074/jbc.M404673200 | doi-access = free }}
* {{cite journal | vauthors = Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, Eklund R, Nopola-Hemmi J, Kääriäinen H, Kere J | title = The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia | journal = PLOS Genetics | volume = 1 | issue = 4 | pages = e50 | date = Oct 2005 | pmid = 16254601 | pmc = 1270007 | doi = 10.1371/journal.pgen.0010050 | doi-access = free }}
{{refend}}

== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2318 | title = 5-HT<sub>1F</sub>  | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}
* {{UCSC gene info|HTR1F}}

{{NLM content}}

{{G protein-coupled receptors}}
{{Serotonergics}}

{{DEFAULTSORT:5-Ht1f Receptor}}
[[Category:Serotonin receptors]]



{{Sourceattribution|5-HT1F receptor}}