Biology:5-HT1F receptor

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

5-hydroxytryptamine (serotonin) receptor 1F, also known as HTR1F is a 5-HT1 receptor protein and also denotes the human gene encoding it.[1][2][3][4][5]

Agonists

  • 5-n-Butyryloxy-DMT:[6] >60-fold selectivity versus 5-HT1E receptor
  • BRL-54443 - mixed 5-HT1E/1F agonist
  • Eletriptan - mixed 5-HT1B/1D/1E/1F/2B/7 agonist
  • LY-334,370[7] - as well as related benzamides[8]
  • LY-344,864 (N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide)
  • Naratriptan - mixed 5-HT1B/1D/1F agonist
  • Lasmiditan - selective 5-HT1F agonist, a first-in-class ditan molecule

Antagonists

MLS000756415[9]

See also

References

  1. ↑ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3355. 
  2. ↑ "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America 90 (2): 408–12. Jan 1993. doi:10.1073/pnas.90.2.408. PMID 8380639. Bibcode: 1993PNAS...90..408A. 
  3. ↑ "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America 90 (6): 2184–8. Mar 1993. doi:10.1073/pnas.90.6.2184. PMID 8384716. Bibcode: 1993PNAS...90.2184L. 
  4. ↑ "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Molecular Membrane Biology 14 (3): 133–5. 1997. doi:10.3109/09687689709048173. PMID 9394293. 
  5. ↑ "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics 77 (5): 415–20. Jun 1998. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173. 
  6. ↑ "Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships". The Journal of Pharmacology and Experimental Therapeutics 337 (3): 860–7. Jun 2011. doi:10.1124/jpet.111.179606. PMID 21422162. 
  7. ↑ "[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn-Schmiedeberg's Archives of Pharmacology 371 (3): 169–77. Mar 2005. doi:10.1007/s00210-005-1035-9. PMID 15900510. 
  8. ↑ "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorganic & Medicinal Chemistry Letters 14 (24): 6011–6. Dec 2004. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719. 
  9. ↑ PudChem: MLS000756415

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.





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