View source for Biology:9,12-octadecadienoate 8-hydroperoxide 8R-isomerase

{{Short description|Class of enzymes}}
{{Infobox enzyme
| Name       = 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase
| EC_number  = 5.4.4.5
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''9,12-octadecadienoate 8-hydroperoxide 8R-isomerase''' ({{EnzExplorer|5.4.4.5}}, ''5,8-LDS (bifunctional enzyme)'', ''5,8-linoleate diol synthase (bifunctional enzyme)'', ''8-hydroperoxide isomerase'', ''(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming)'', ''PpoA'') is an [[Biology:Enzyme|enzyme]] with [[Biology:List of enzymes|systematic name]] ''(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase ((5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate-forming)''.<ref>{{cite journal | vauthors = Hoffmann I, Jernerén F, Garscha U, Oliw EH | title = Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase | journal = Archives of Biochemistry and Biophysics | volume = 506 | issue = 2 | pages = 216–22 | date = February 2011 | pmid = 21130068 | doi = 10.1016/j.abb.2010.11.022 }}</ref><ref>{{cite journal | vauthors = Jernerén F, Garscha U, Hoffmann I, Hamberg M, Oliw EH | title = Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus | journal = Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | volume = 1801 | issue = 4 | pages = 503–7 | date = April 2010 | pmid = 20045744 | doi = 10.1016/j.bbalip.2009.12.012 }}</ref><ref>{{cite journal | vauthors = Brodhun F, Göbel C, Hornung E, Feussner I | title = Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450 | journal = The Journal of Biological Chemistry | volume = 284 | issue = 18 | pages = 11792–805 | date = May 2009 | pmid = 19286665 | pmc = 2673248 | doi = 10.1074/jbc.M809152200 | doi-access = free }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]

: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <math>\rightleftharpoons</math> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate

This enzyme contains [[Biology:Heme|heme]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|9,12-octadecadienoate+8-hydroperoxide+8R-isomerase}}

{{Mutases}}
{{Enzymes}}

[[Category:EC 5.4.4]]

{{Sourceattribution|9,12-octadecadienoate 8-hydroperoxide 8R-isomerase}}