Biology:9,12-octadecadienoate 8-hydroperoxide 8R-isomerase
From HandWiki
Short description: Class of enzymes
| 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.4.5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
9,12-octadecadienoate 8-hydroperoxide 8R-isomerase (EC 5.4.4.5, 5,8-LDS (bifunctional enzyme), 5,8-linoleate diol synthase (bifunctional enzyme), 8-hydroperoxide isomerase, (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming), PpoA) is an enzyme with systematic name (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase ((5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate [math]\displaystyle{ \rightleftharpoons }[/math] (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate
This enzyme contains heme.
References
- ↑ "Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase". Archives of Biochemistry and Biophysics 506 (2): 216–22. February 2011. doi:10.1016/j.abb.2010.11.022. PMID 21130068.
- ↑ "Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801 (4): 503–7. April 2010. doi:10.1016/j.bbalip.2009.12.012. PMID 20045744.
- ↑ "Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450". The Journal of Biological Chemistry 284 (18): 11792–805. May 2009. doi:10.1074/jbc.M809152200. PMID 19286665.
External links
- 9,12-octadecadienoate+8-hydroperoxide+8R-isomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
