View source for Biology:CLC (gene)

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Galectin-10''' is an [[Biology:Enzyme|enzyme]] that in humans is encoded by the ''CLC'' [[Biology:Gene|gene]].<ref name="pmid1577491">{{cite journal | vauthors = Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ | title = Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14 | journal = Genomics | volume = 13 | issue = 1 | pages = 240–2 |date=Jun 1992 | pmid = 1577491 | doi =10.1016/0888-7543(92)90237-M  }}</ref><ref name="entrez">{{cite web | title = CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1178}}</ref>

[[Biology:Lysophospholipase|Lysophospholipase]]s are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in [[Biology:Eosinophil|eosinophil]]s and [[Biology:Basophil|basophil]]s. It hydrolyzes [[Chemistry:Lysophosphatidylcholine|lysophosphatidylcholine]] to glycerophosphocholine and a free [[Chemistry:Fatty acid|fatty acid]]. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the [[Biology:Galectin|galectin]] family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.<ref name="entrez" />

==See also==
* Charcot-Leyden crystals

==References==
{{reflist}}

==External links==
* {{UCSC gene info|CLC}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Gleich GJ, Loegering DA, Mann KG, Maldonado JE |title=Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils |journal=J. Clin. Invest. |volume=57 |issue= 3 |pages= 633–40 |year= 1976 |pmid= 942977 |doi=10.1172/JCI108319  | pmc=436696  }}
*{{cite journal  | vauthors=Golightly LM, Thomas LL, Dvorak AM, Ackerman SJ |title=Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils |journal=J. Leukoc. Biol. |volume=51 |issue= 4 |pages= 386–92 |year= 1992 |pmid= 1373430 |doi=  10.1002/jlb.51.4.386|s2cid=24236041 }}
*{{cite journal  | author=Dvorak AM |title=Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome |journal=Lab. Invest. |volume=62 |issue= 5 |pages= 590–607 |year= 1990 |pmid= 2160562 |name-list-style=vanc| author2=Weller PF  | author3=Monahan-Earley RA  | display-authors=3  | last4=Letourneau  | first4=L  | last5=Ackerman  | first5=SJ  }}
*{{cite journal  | vauthors=Dvorak AM, Letourneau L, Weller PF, Ackerman SJ |title=Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas |journal=Lab. Invest. |volume=62 |issue= 5 |pages= 608–15 |year= 1990 |pmid= 2160563 }}
*{{cite journal  | vauthors=Dvorak AM, Ackerman SJ |title=Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to granules and intragranular crystals in mature human basophils |journal=Lab. Invest. |volume=60 |issue= 4 |pages= 557–67 |year= 1989 |pmid= 2709814 |doi=10.1111/1523-1747.ep12703656  |doi-access=free }}
*{{cite journal  | author=Sieker LC |title=Crystallographic characterization of human eosinophil Charcot-Leyden crystals |journal=J. Mol. Biol. |volume=204 |issue= 2 |pages= 489–91 |year= 1989 |pmid= 3221396 |doi=10.1016/0022-2836(88)90590-6  |name-list-style=vanc| author2=Turley S  | author3=Le Trong I  | display-authors=3  | last4=Stenkamp  | first4=R  | last5=Weller  | first5=P  | last6=Ackerman  | first6=S  }}
*{{cite journal  | vauthors=Weller PF, Bach D, Austen KF |title=Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals |journal=J. Immunol. |volume=128 |issue= 3 |pages= 1346–9 |year= 1982 |pmid= 6173432 }}
*{{cite journal  | vauthors=Weller PF, Bach DS, Austen KF |title=Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase) |journal=J. Biol. Chem. |volume=259 |issue= 24 |pages= 15100–5 |year= 1985 |doi=10.1016/S0021-9258(17)42520-8 |pmid= 6511787 |doi-access=free }}
*{{cite journal  | author=Gomolin HI |title=Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter |journal=Blood |volume=82 |issue= 6 |pages= 1868–74 |year= 1993 |pmid= 8400237 |doi=  10.1182/blood.V82.6.1868.1868|name-list-style=vanc| author2=Yamaguchi Y  | author3=Paulpillai AV  | display-authors=3  | last4=Dvorak  | first4=LA  | last5=Ackerman  | first5=SJ  | last6=Tenen  | first6=DG  | doi-access=free}}
*{{cite journal  | author=Ackerman SJ |title=Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily |journal=J. Immunol. |volume=150 |issue= 2 |pages= 456–68 |year= 1993 |pmid= 8419478 |name-list-style=vanc| author2=Corrette SE  | author3=Rosenberg HF  | display-authors=3  | last4=Bennett  | first4=JC  | last5=Mastrianni  | first5=DM  | last6=Nicholson-Weller  | first6=A  | last7=Weller  | first7=PF  | last8=Chin  | first8=DT  | last9=Tenen  | first9=DG  }}
*{{cite journal  | author=Leonidas DD |title=Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins |journal=Structure |volume=3 |issue= 12 |pages= 1379–93 |year= 1996 |pmid= 8747464 |doi=10.1016/S0969-2126(01)00275-1  |name-list-style=vanc| author2=Elbert BL  | author3=Zhou Z  | display-authors=3  | last4=Leffler  | first4=Hakon  | last5=Ackerman  | first5=Steven J  | last6=Acharya  | first6=K.Ravi  | doi-access=free  }}
*{{cite journal  | vauthors=Dyer KD, Handen JS, Rosenberg HF |title=The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes |journal=Genomics |volume=40 |issue= 2 |pages= 217–21 |year= 1997 |pmid= 9119387 |doi= 10.1006/geno.1996.4590 |url=https://zenodo.org/record/1229719 }}
*{{cite journal  | author=Swaminathan GJ |title=Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution |journal=Biochemistry |volume=38 |issue= 42 |pages= 13837–43 |year= 1999 |pmid= 10529229 |doi=10.1021/bi990756e  |name-list-style=vanc| author2=Leonidas DD  | author3=Savage MP  | display-authors=3  | last4=Ackerman  | first4=Steven J.  | last5=Acharya  | first5=K. Ravi  }}
*{{cite journal  | author=Larramendy ML |title=Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis |journal=Haematologica |volume=87 |issue= 6 |pages= 569–77 |year= 2003 |pmid= 12031912 |name-list-style=vanc| author2=Niini T  | author3=Elonen E  | display-authors=3  | last4=Nagy  | first4=B  | last5=Ollila  | first5=J  | last6=Vihinen  | first6=M  | last7=Knuutila  | first7=S  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  | author=Abedin MJ |title=Potential roles of galectins in myeloid differentiation into three different lineages |journal=J. Leukoc. Biol. |volume=73 |issue= 5 |pages= 650–6 |year= 2003 |pmid= 12714580 |doi=10.1189/jlb.0402163  |name-list-style=vanc| author2=Kashio Y  | author3=Seki M  | display-authors=3  | last4=Nakamura  | first4=K  | last5=Hirashima  | first5=M  |s2cid=21337581 |doi-access=free}}
*{{cite journal  | author=Grimwood J |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399  |name-list-style=vanc| author2=Gordon LA  | author3=Olsen A  | display-authors=3  | last4=Terry  | first4=Astrid  | last5=Schmutz  | first5=Jeremy  | last6=Lamerdin  | first6=Jane  | last7=Hellsten  | first7=Uffe  | last8=Goodstein  | first8=David  | last9=Couronne  | first9=Olivier |bibcode=2004Natur.428..529G | doi-access=free  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-style=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Nielsen K |title=Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients |journal=Cornea |volume=24 |issue= 6 |pages= 661–8 |year= 2005 |pmid= 16015083 |doi=10.1097/01.ico.0000153556.59407.69  |name-list-style=vanc| author2=Heegaard S  | author3=Vorum H  | display-authors=3  | last4=Birkenkamp-Demtr??Der  | first4=Karin  | last5=Ehlers  | first5=Niels  | last6=Orntoft  | first6=Torben Falck  |s2cid=21026845 }}
{{refend}}
{{PDB Gallery|geneid=1178}}




{{Sourceattribution|CLC (gene)|1}}