Biology:CLC (gene)

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Galectin-10 is an enzyme that in humans is encoded by the CLC gene.

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.

See also

• Charcot-Leyden crystals

External links

• Human CLC genome location and CLC gene details page in the UCSC Genome Browser.

Further reading

• "Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils". J. Clin. Invest. 57 (3): 633–40. 1976. doi:10.1172/JCI108319. PMID 942977. 
• "Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils". J. Leukoc. Biol. 51 (4): 386–92. 1992. doi:10.1002/jlb.51.4.386. PMID 1373430. 
• Dvorak AM; Weller PF; Monahan-Earley RA et al. (1990). "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome". Lab. Invest. 62 (5): 590–607. PMID 2160562. 
• "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas". Lab. Invest. 62 (5): 608–15. 1990. PMID 2160563. 
• "Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to granules and intragranular crystals in mature human basophils". Lab. Invest. 60 (4): 557–67. 1989. doi:10.1111/1523-1747.ep12703656. PMID 2709814. 
• Sieker LC; Turley S; Le Trong I et al. (1989). "Crystallographic characterization of human eosinophil Charcot-Leyden crystals". J. Mol. Biol. 204 (2): 489–91. doi:10.1016/0022-2836(88)90590-6. PMID 3221396. 
• "Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals". J. Immunol. 128 (3): 1346–9. 1982. PMID 6173432. 
• "Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase)". J. Biol. Chem. 259 (24): 15100–5. 1985. doi:10.1016/S0021-9258(17)42520-8. PMID 6511787. 
• Gomolin HI; Yamaguchi Y; Paulpillai AV et al. (1993). "Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter". Blood 82 (6): 1868–74. doi:10.1182/blood.V82.6.1868.1868. PMID 8400237. 
• Ackerman SJ; Corrette SE; Rosenberg HF et al. (1993). "Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily". J. Immunol. 150 (2): 456–68. PMID 8419478. 
• Leonidas DD; Elbert BL; Zhou Z et al. (1996). "Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins". Structure 3 (12): 1379–93. doi:10.1016/S0969-2126(01)00275-1. PMID 8747464. 
• "The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes". Genomics 40 (2): 217–21. 1997. doi:10.1006/geno.1996.4590. PMID 9119387. https://zenodo.org/record/1229719. 
• Swaminathan GJ; Leonidas DD; Savage MP et al. (1999). "Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution". Biochemistry 38 (42): 13837–43. doi:10.1021/bi990756e. PMID 10529229. 
• Larramendy ML; Niini T; Elonen E et al. (2003). "Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis". Haematologica 87 (6): 569–77. PMID 12031912. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Abedin MJ; Kashio Y; Seki M et al. (2003). "Potential roles of galectins in myeloid differentiation into three different lineages". J. Leukoc. Biol. 73 (5): 650–6. doi:10.1189/jlb.0402163. PMID 12714580. 
• Grimwood J; Gordon LA; Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
• Nielsen K; Heegaard S; Vorum H et al. (2005). "Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients". Cornea 24 (6): 661–8. doi:10.1097/01.ico.0000153556.59407.69. PMID 16015083.