View source for Biology:D-Man-alpha-(1-3)-D-Glc-beta-(1-4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase

{{Short description|Class of enzymes}}
{{Infobox enzyme
| Name       = D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase
| EC_number  = 2.4.1.264
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase''' ({{EC number|2.4.1.264}}, ''GumK'') is an [[Biology:Enzyme|enzyme]] with the [[Biology:List of enzymes|systematic name]] ''UDP-glucuronate: D-Man-alpha-(1->3) -D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol beta-1,2-glucuronyltransferase''.<ref>{{cite journal | vauthors = Katzen F, Ferreiro DU, Oddo CG, Ielmini MV, Becker A, Pühler A, Ielpi L | title = Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence | journal = Journal of Bacteriology | volume = 180 | issue = 7 | pages = 1607–17 | date = April 1998 | pmid = 9537354 | pmc = 107069 }}</ref><ref>{{cite journal | vauthors = Ielpi L, Couso RO, Dankert MA | title = Sequential assembly and polymerization of the polyprenol-linked pentasaccharide repeating unit of the xanthan polysaccharide in Xanthomonas campestris | journal = Journal of Bacteriology | volume = 175 | issue = 9 | pages = 2490–500 | date = May 1993 | pmid = 7683019 | pmc = 204549 }}</ref><ref>{{cite journal | vauthors = Kim SY, Kim JG, Lee BM, Cho JY | title = Mutational analysis of the gum gene cluster required for xanthan biosynthesis in Xanthomonas oryzae pv oryzae | journal = Biotechnology Letters | volume = 31 | issue = 2 | pages = 265–70 | date = February 2009 | pmid = 18854951 | doi = 10.1007/s10529-008-9858-3 }}</ref><ref>{{cite journal | vauthors = Barreras M, Bianchet MA, Ielpi L | title = Crystallization and preliminary crystallographic characterization of GumK, a membrane-associated glucuronosyltransferase from Xanthomonas campestris required for xanthan polysaccharide synthesis | journal = Acta Crystallographica. Section F, Structural Biology and Crystallization Communications | volume = 62 | issue = Pt 9 | pages = 880–3 | date = September 2006 | pmid = 16946469 | pmc = 2242869 | doi = 10.1107/S1744309106028764 }}</ref><ref>{{cite journal | vauthors = Barreras M, Salinas SR, Abdian PL, Kampel MA, Ielpi L | title = Structure and mechanism of GumK, a membrane-associated glucuronosyltransferase | journal = The Journal of Biological Chemistry | volume = 283 | issue = 36 | pages = 25027–35 | date = September 2008 | pmid = 18596046 | pmc = 3259810 | doi = 10.1074/jbc.M801227200 }}</ref><ref>{{cite journal | vauthors = Vojnov AA, Bassi DE, Daniels MJ, Dankert MA | title = Biosynthesis of a substituted cellulose from a mutant strain of Xanthomonas campestris | journal = Carbohydrate Research | volume = 337 | issue = 4 | pages = 315–26 | date = February 2002 | pmid = 11841812 | doi = 10.1016/S0008-6215(01)00322-6 }}</ref><ref>{{cite journal | vauthors = Barreras M, Abdian PL, Ielpi L | title = Functional characterization of GumK, a membrane-associated beta-glucuronosyltransferase from Xanthomonas campestris required for xanthan polysaccharide synthesis | journal = Glycobiology | volume = 14 | issue = 3 | pages = 233–41 | date = March 2004 | pmid = 14736729 | doi = 10.1093/glycob/cwh056 | doi-access = free }}</ref> This enzyme [[Chemistry:Catalysis|catalyses]] the following [[Chemistry:Chemical reaction|chemical reaction]]:

: UDP-glucuronate + D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol <math>\rightleftharpoons</math> UDP + D-GlcA-beta-(1->2) -D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

The enzyme is involved in the biosynthesis of the exopolysaccharides xanthan (in the bacterium ''[[Biology:Xanthomonas campestris|Xanthomonas campestris]]'') and acetan (in the bacterium ''Gluconacetobacter xylinus'').

== References ==
{{reflist}}

== External links ==
*{{MeshName|D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol+2-beta-glucuronyltransferase}}

{{Glycosyltransferases}}
{{Enzymes}}

[[Category:EC 2.4.1]]

{{Sourceattribution|D-Man-alpha-(1-3)-D-Glc-beta-(1-4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase}}