Biology:D-Man-alpha-(1-3)-D-Glc-beta-(1-4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase
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Short description: Class of enzymes
| D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.264 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronyltransferase (EC 2.4.1.264, GumK) is an enzyme with the systematic name UDP-glucuronate: D-Man-alpha-(1->3) -D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol beta-1,2-glucuronyltransferase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction:
- UDP-glucuronate + D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [math]\displaystyle{ \rightleftharpoons }[/math] UDP + D-GlcA-beta-(1->2) -D-Man-alpha-(1->3) -D-Glc-beta-(1->4) -D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol
The enzyme is involved in the biosynthesis of the exopolysaccharides xanthan (in the bacterium Xanthomonas campestris) and acetan (in the bacterium Gluconacetobacter xylinus).
References
- ↑ "Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence". Journal of Bacteriology 180 (7): 1607–17. April 1998. PMID 9537354.
- ↑ "Sequential assembly and polymerization of the polyprenol-linked pentasaccharide repeating unit of the xanthan polysaccharide in Xanthomonas campestris". Journal of Bacteriology 175 (9): 2490–500. May 1993. PMID 7683019.
- ↑ "Mutational analysis of the gum gene cluster required for xanthan biosynthesis in Xanthomonas oryzae pv oryzae". Biotechnology Letters 31 (2): 265–70. February 2009. doi:10.1007/s10529-008-9858-3. PMID 18854951.
- ↑ "Crystallization and preliminary crystallographic characterization of GumK, a membrane-associated glucuronosyltransferase from Xanthomonas campestris required for xanthan polysaccharide synthesis". Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 62 (Pt 9): 880–3. September 2006. doi:10.1107/S1744309106028764. PMID 16946469.
- ↑ "Structure and mechanism of GumK, a membrane-associated glucuronosyltransferase". The Journal of Biological Chemistry 283 (36): 25027–35. September 2008. doi:10.1074/jbc.M801227200. PMID 18596046.
- ↑ "Biosynthesis of a substituted cellulose from a mutant strain of Xanthomonas campestris". Carbohydrate Research 337 (4): 315–26. February 2002. doi:10.1016/S0008-6215(01)00322-6. PMID 11841812.
- ↑ "Functional characterization of GumK, a membrane-associated beta-glucuronosyltransferase from Xanthomonas campestris required for xanthan polysaccharide synthesis". Glycobiology 14 (3): 233–41. March 2004. doi:10.1093/glycob/cwh056. PMID 14736729.
External links
- >3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol%202-beta-glucuronyltransferase D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol+2-beta-glucuronyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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