View source for Biology:HDAC10

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Histone deacetylase 10''' is an [[Biology:Enzyme|enzyme]] that in humans is encoded by the ''HDAC10'' [[Biology:Gene|gene]].<ref name="pmid11677242">{{cite journal |vauthors=Kao HY, Lee CH, Komarov A, Han CC, Evans RM | title = Isolation and characterization of mammalian HDAC10, a novel histone deacetylase | journal = J Biol Chem | volume = 277 | issue = 1 | pages = 187–93 |date=Jan 2002 | pmid = 11677242 | doi = 10.1074/jbc.M108931200 | doi-access =  free}}</ref><ref name="pmid11726666">{{cite journal |vauthors=Guardiola AR, Yao TP | title = Molecular cloning and characterization of a novel histone deacetylase HDAC10 | journal = J Biol Chem | volume = 277 | issue = 5 | pages = 3350–6 |date=Jan 2002 | pmid = 11726666 | doi = 10.1074/jbc.M109861200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HDAC10 histone deacetylase 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83933}}</ref>

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM]<ref name="entrez" />

==Interactions==
HDAC10 has been shown to interact with [[Biology:Histone deacetylase 2|Histone deacetylase 2]]<ref name=pmid11739383>{{cite journal |last=Fischer |first=Denise D |author2=Cai Richard |author3=Bhatia Umesh |author4=Asselbergs Fred A M |author5=Song Chuanzheng |author6=Terry Robert |author7=Trogani Nancy |author8=Widmer Roland |author9=Atadja Peter |author10=Cohen Dalia  |date=Feb 2002 |title=Isolation and characterization of a novel class II histone deacetylase, HDAC10 |journal=J. Biol. Chem. |volume=277 |issue=8 |pages=6656–66 |location = United States| issn = 0021-9258| pmid = 11739383 |doi = 10.1074/jbc.M108055200 |doi-access=free }}</ref> and [[Biology:Nuclear receptor co-repressor 2|Nuclear receptor co-repressor 2]].<ref name=pmid11739383/>

==See also==
* [[Biology:Histone deacetylase|Histone deacetylase]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  |doi-access=free }}
*{{cite journal  | author=Dunham I |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031  |name-list-style=vanc| author2=Shimizu N  | author3=Roe BA  | display-authors=3  | last4=Bruskiewich  | first4=R.  | last5=Beare  | first5=D. M.  | last6=Clamp  | first6=M.  | last7=Smink  | first7=L. J.  | last8=Ainscough  | first8=R.  | last9=Almeida  | first9=J. P. |bibcode=1999Natur.402..489D| doi-access=free  }}
*{{cite journal  | author=Fischer DD |title=Isolation and characterization of a novel class II histone deacetylase, HDAC10 |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6656–66 |year= 2002 |pmid= 11739383 |doi= 10.1074/jbc.M108055200  |name-list-style=vanc| author2=Cai R  | author3=Bhatia U  | display-authors=3  | last4=Asselbergs  | first4=FA  | last5=Song  | first5=C  | last6=Terry  | first6=R  | last7=Trogani  | first7=N  | last8=Widmer  | first8=R  | last9=Atadja  | first9=P | doi-access=free  }}
*{{cite journal  |vauthors=Tong JJ, Liu J, Bertos NR, Yang XJ |title=Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain |journal=Nucleic Acids Res. |volume=30 |issue= 5 |pages= 1114–23 |year= 2002 |pmid= 11861901 |doi=10.1093/nar/30.5.1114  | pmc=101247  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M|doi-access=free }}
*{{cite journal  |vauthors=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200 |doi-access= free }}
*{{cite journal  |vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8  | pmc=395752 |doi-access=free }}
*{{cite journal  | author=Osada H |title=Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients |journal=Int. J. Cancer |volume=112 |issue= 1 |pages= 26–32 |year= 2004 |pmid= 15305372 |doi= 10.1002/ijc.20395  |name-list-style=vanc| author2=Tatematsu Y  | author3=Saito H  | display-authors=3  | last4=Yatabe  | first4=Yasushi  | last5=Mitsudomi  | first5=Tetsuya  | last6=Takahashi  | first6=Takashi |s2cid=23452893 |doi-access=free}}
*{{cite journal  | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84  | pmc=545604  |name-list-style=vanc| author2=Wright CL  | author3=Edwards CA  | display-authors=3  | last4=Davis  | first4=Matthew P  | last5=Grinham  | first5=James A  | last6=Cole  | first6=Charlotte G  | last7=Goward  | first7=Melanie E  | last8=Aguado  | first8=Begoña  | last9=Mallya  | first9=Meera |doi-access=free }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-style=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
{{refend}}

== External links ==
* {{MeshName|HDAC10+protein,+human}}

{{NLM content}}
{{Carbon-nitrogen non-peptide hydrolases}}
{{Enzymes}}

[[Category:EC 3.5.1]]



{{Sourceattribution|HDAC10}}