Biology:HDAC10
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene.[1][2][3] HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8-acetylspermidine. [4]
Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM][3]
Interactions
HDAC10 has been shown to interact with Histone deacetylase 2[5] and Nuclear receptor co-repressor 2.[5]
See also
References
- ↑ "Isolation and characterization of mammalian HDAC10, a novel histone deacetylase". The Journal of Biological Chemistry 277 (1): 187–193. January 2002. doi:10.1074/jbc.M108931200. PMID 11677242.
- ↑ "Molecular cloning and characterization of a novel histone deacetylase HDAC10". The Journal of Biological Chemistry 277 (5): 3350–3356. February 2002. doi:10.1074/jbc.M109861200. PMID 11726666.
- ↑ 3.0 3.1 "Entrez Gene: HDAC10 histone deacetylase 10". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=83933.
- ↑ "Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors". Current Opinion in Structural Biology 82. October 2023. doi:10.1016/j.sbi.2023.102668. PMID 37542907.
- ↑ 5.0 5.1 "Isolation and characterization of a novel class II histone deacetylase, HDAC10". The Journal of Biological Chemistry 277 (8): 6656–6666. February 2002. doi:10.1074/jbc.M108055200. PMID 11739383.
Further reading
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. September 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–495. December 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Isolation and characterization of a novel class II histone deacetylase, HDAC10". The Journal of Biological Chemistry 277 (8): 6656–6666. February 2002. doi:10.1074/jbc.M108055200. PMID 11739383.
- "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain". Nucleic Acids Research 30 (5): 1114–1123. March 2002. doi:10.1093/nar/30.5.1114. PMID 11861901.
- "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". The Journal of Biological Chemistry 278 (52): 52914–52918. December 2003. doi:10.1074/jbc.C300407200. PMID 14578343.
- "An unappreciated role for RNA surveillance". Genome Biology 5 (2). 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- "Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients". International Journal of Cancer 112 (1): 26–32. October 2004. doi:10.1002/ijc.20395. PMID 15305372.
- "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology 5 (10). 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
External links
- HDAC10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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