View source for Biology:Myosin-heavy-chain kinase

{{infobox enzyme
| Name       = myosin heavy chain kinase
| EC_number  = 2.7.11.7
| CAS_number = 64763-54-8
| GO_code    = 0016905
| image      =
| width      = 
| caption    =  
}}
In [[Biology:Enzymology|enzymology]], a '''myosin-heavy-chain kinase''' ({{EC number|2.7.11.7}}) is an [[Biology:Enzyme|enzyme]] that [[Chemistry:Catalysis|catalyzes]] the [[Chemistry:Chemical reaction|chemical reaction]]

:ATP + [myosin heavy-chain] <math>\rightleftharpoons</math> ADP + [myosin heavy-chain] phosphate

Thus, the two [[Biology:Substrate (biochemistry)|substrates]] of this enzyme are [[Chemistry:Adenosine triphosphate|ATP]] and myosin heavy-chain, whereas its two [[Chemistry:Product|products]] are [[Chemistry:Adenosine diphosphate|ADP]] and myosin heavy-chain phosphate.

This enzyme belongs to the family of [[Biology:Transferase|transferase]]s, specifically those transferring a phosphate group to the sidechain [[Chemistry:Oxygen|oxygen]] atom of [[Chemistry:Serine|serine]] or [[Chemistry:Threonine|threonine]] residues in [[Biology:Protein|protein]]s (protein-serine/threonine kinases). The [[Biology:List of enzymes|systematic name]] of this enzyme class is '''ATP:[myosin heavy-chain] O-phosphotransferase'''. Other names in common use include
*ATP:myosin-heavy-chain O-phosphotransferase
*calmodulin-dependent myosin heavy chain kinase
*MHCK
*MIHC kinase
*myosin heavy chain kinase
*myosin I heavy-chain kinase
*myosin II heavy-chain kinase
*[myosin-heavy-chain] kinase
*myosin heavy chain kinase A
*STK6.

==References==
{{Reflist}}
* {{cite journal |vauthors=Cote GP, Bukiejko U | date = 1987 | title = Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum | journal = J. Biol. Chem. | volume = 262 | pages = 1065–72  | pmid = 3027076 | issue = 3 | doi = 10.1016/S0021-9258(19)75750-0 | doi-access = free }}
* {{cite journal | vauthors = ((Hammer JA III)), Albanesi JP, Korn ED | date = 1983 | title = Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii | journal = J. Biol. Chem. | volume = 258 | pages = 10168–75  | pmid = 6309772 | issue = 16 | doi = 10.1016/S0021-9258(17)44620-5 | doi-access = free }}
* {{cite journal |vauthors=Rieker JP, Swanljung-Collins H, Collins JH | date = 1987 | title = Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border | journal = J. Biol. Chem. | volume = 262 | pages = 15262–8  | pmid = 2822719 | issue = 31 | doi = 10.1016/S0021-9258(18)48169-0 | doi-access = free }}
* {{cite journal |vauthors=Ravid S, Spudich JA | date = 1989 | title = Myosin heavy chain kinase from developed Dictyostelium cells Purification and characterization | journal = J. Biol. Chem. | volume = 264 | pages = 15144–50  | pmid = 2549052 | issue = 25 | doi = 10.1016/S0021-9258(18)63823-2 | doi-access = free }}
* {{cite journal |vauthors=Brzeska H, Lynch TJ, Martin B, Corigliano-Murphy A, Korn ED | date = 1990 | title = Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides | journal = J. Biol. Chem. | volume = 265 | pages = 16138–44  | pmid = 2168881 | issue = 27 | doi = 10.1016/S0021-9258(17)46199-0 | doi-access = free }}
* {{cite journal |vauthors=Ravid S, Spudich JA | date = 1992 | title = Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | pages = 5877–81  | pmid = 1321427 | doi = 10.1073/pnas.89.13.5877 | issue = 13 | pmc = 49400 | bibcode = 1992PNAS...89.5877R | doi-access = free }}
* {{cite journal |vauthors=Futey LM, Medley QG, Cote GP, Egelhoff TT | date = 1995 | title = Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins | journal = J. Biol. Chem. | volume = 270 | pages = 523–9  | pmid = 7822274 | doi = 10.1074/jbc.270.2.523 | issue = 2 | doi-access = free }}
* {{cite journal |vauthors=Korn ED, Brzeska H | date = 1998 | title = Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | pages = 4146–51  | pmid = 9539704 | doi = 10.1073/pnas.95.8.4146 | issue = 8 | pmc = 22456 | bibcode = 1998PNAS...95.4146S | doi-access = free }}
* {{cite journal |vauthors=Egelhoff TT, Croft D, Steimle PA | date = 2005 | title = Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly | journal = J. Biol. Chem. | volume = 280 | pages = 2879–87  | pmid = 15545285 | doi = 10.1074/jbc.M410803200 | issue = 4 | doi-access = free }}

{{Serine/threonine-specific protein kinases}}
{{Enzymes}}

[[Category:EC 2.7.11]]
[[Category:Enzymes of unknown structure]]



{{Sourceattribution|Myosin-heavy-chain kinase}}