Biology:Myosin-heavy-chain kinase

From HandWiki
myosin heavy chain kinase
Identifiers
EC number2.7.11.7
CAS number64763-54-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a myosin-heavy-chain kinase (EC 2.7.11.7) is an enzyme that catalyzes the chemical reaction

ATP + [myosin heavy-chain] [math]\displaystyle{ \rightleftharpoons }[/math] ADP + [myosin heavy-chain] phosphate

Thus, the two substrates of this enzyme are ATP and myosin heavy-chain, whereas its two products are ADP and myosin heavy-chain phosphate.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[myosin heavy-chain] O-phosphotransferase. Other names in common use include

  • ATP:myosin-heavy-chain O-phosphotransferase
  • calmodulin-dependent myosin heavy chain kinase
  • MHCK
  • MIHC kinase
  • myosin heavy chain kinase
  • myosin I heavy-chain kinase
  • myosin II heavy-chain kinase
  • [myosin-heavy-chain] kinase
  • myosin heavy chain kinase A
  • STK6.

References