View source for Biology:Succinate—CoA ligase (GDP-forming)

{{infobox enzyme
| Name       = succinate—CoA ligase (GDP-forming)
| EC_number  = 6.2.1.4
| CAS_number = 9014-36-2
| GO_code    = 0004776
| image      = 2fp4.png
| width      =
| caption    = Pig GTP-specific succinyl-CoA synthetase with GTP. PDB {{PDBe|2fp4}} <ref>{{Cite journal 
| last1 = Fraser | first1 = M. E. 
| last2 = Hayakawa | first2 = K. 
| last3 = Hume | first3 = M. S. 
| last4 = Ryan | first4 = D. G. 
| last5 = Brownie | first5 = E. R. 
| title = Interactions of GTP with the ATP-grasp Domain of GTP-specific Succinyl-CoA Synthetase 
| doi = 10.1074/jbc.M511785200 
| journal = Journal of Biological Chemistry 
| volume = 281 
| issue = 16 
| pages = 11058–11065 
| year = 2006 
| pmid = 16481318 
| pmc = 
| doi-access = free 
}}</ref> 
}}
In [[Biology:Enzymology|enzymology]], a '''succinate—CoA ligase (GDP-forming)''' ({{EnzExplorer|6.2.1.4}}) is an [[Biology:Enzyme|enzyme]] that [[Chemistry:Catalysis|catalyzes]] the [[Chemistry:Chemical reaction|chemical reaction]]

:GTP + succinate + CoA <math>\rightleftharpoons</math> GDP + phosphate + succinyl-CoA

The 3 [[Biology:Substrate (biochemistry)|substrates]] of this enzyme are [[Chemistry:Guanosine triphosphate|GTP]], succinate, and [[Chemistry:Coenzyme A|CoA]], whereas its 3 [[Chemistry:Product|products]] are [[Chemistry:Guanosine diphosphate|GDP]], [[Chemistry:Phosphate|phosphate]], and [[Chemistry:Succinyl-CoA|succinyl-CoA]].

This enzyme belongs to the family of [[Biology:Ligase|ligase]]s, specifically those forming carbon-sulfur bonds as acid-thiol ligases.  The [[Biology:List of enzymes|systematic name]] of this enzyme class is '''succinate:CoA ligase (GDP-forming)'''. Other names in common use include '''succinyl-CoA synthetase (GDP-forming)''', '''succinyl coenzyme A synthetase (guanosine diphosphate-forming)''', '''succinate thiokinase''', '''succinic thiokinase''', '''succinyl coenzyme A synthetase''', '''succinate-phosphorylating enzyme''', '''P-enzyme''', '''SCS''', '''G-STK''', '''succinyl coenzyme A synthetase (GDP-forming)''', '''succinyl CoA synthetase''', and '''succinyl coenzyme A synthetase'''.  This enzyme participates in the [[Biology:Citric acid cycle|citric acid cycle]] and propanoate metabolism.

==Structural studies==

As of late 2007, 6 [[Biology:Tertiary structure|structures]] have been solved for this class of enzymes, with [[Biology:Protein Data Bank|PDB]] accession codes {{PDB link|1EUC}}, {{PDB link|1EUD}}, {{PDB link|2FP4}}, {{PDB link|2FPG}}, {{PDB link|2FPI}}, and {{PDB link|2FPP}}.

==References==
{{reflist|1}}
* Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p.&nbsp;387-399.
* {{cite journal | vauthors = Kaufman S, Gilvarg C, Cori O, Ochoa S | year = 1953 | title = Enzymatic oxidation of alpha-ketoglutarate and coupled phosphorylation | journal = J. Biol. Chem.  | volume = 203 | issue = 2 | pages = 869&ndash;888 | pmid=13084656}}
* {{cite journal | vauthors = Mazumder R, Sanadi DR, Rodwell WV | year = 1960 | title = Purification and properties of hog kidney succinic thiokinase | journal = J. Biol. Chem.  | volume = 235 | pages = 2546&ndash;2550 | pmid=13768680}}
* {{cite journal | vauthors = SANADI DR, GIBSON M, AYENGAR P | year = 1954 | title = Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A | journal = Biochim. Biophys. Acta  | volume = 14 | pages = 434&ndash;6  | pmid = 13181903 | doi = 10.1016/0006-3002(54)90205-X | issue = 3 }}

{{Ligases CO CS and CN}}
{{Enzymes}}

{{DEFAULTSORT:Succinate-CoA ligase (GDP-forming)}}
[[Category:EC 6.2.1]]
[[Category:Enzymes of known structure]]



{{Sourceattribution|Succinate—CoA ligase (GDP-forming)}}