Biology:Succinate—CoA ligase (GDP-forming)

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succinate-CoA ligase (GDP-forming)
Pig GTP-specific succinyl-CoA synthetase with GTP. PDB 2fp4 [1]
EC number6.2.1.4
CAS number9014-36-2
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a succinate-CoA ligase (GDP-forming) (EC is an enzyme that catalyzes the chemical reaction

GTP + succinate + CoA [math]\rightleftharpoons[/math] GDP + phosphate + succinyl-CoA

The 3 substrates of this enzyme are GTP, succinate, and CoA, whereas its 3 products are GDP, phosphate, and succinyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is succinate:CoA ligase (GDP-forming). Other names in common use include succinyl-CoA synthetase (GDP-forming), succinyl coenzyme A synthetase (guanosine diphosphate-forming), succinate thiokinase, succinic thiokinase, succinyl coenzyme A synthetase, succinate-phosphorylating enzyme, P-enzyme, SCS, G-STK, succinyl coenzyme A synthetase (GDP-forming), succinyl CoA synthetase, and succinyl coenzyme A synthetase. This enzyme participates in the citric acid cycle and propanoate metabolism.

Structural studies[edit]

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1EUC, 1EUD, 2FP4, 2FPG, 2FPI, and 2FPP.


  1. Fraser, M. E.; Hayakawa, K.; Hume, M. S.; Ryan, D. G.; Brownie, E. R. (2006). "Interactions of GTP with the ATP-grasp Domain of GTP-specific Succinyl-CoA Synthetase". Journal of Biological Chemistry 281 (16): 11058–11065. doi:10.1074/jbc.M511785200. PMID 16481318. 
  • Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387-399.
  • "Enzymatic oxidation of alpha-ketoglutarate and coupled phosphorylation". J. Biol. Chem. 203: 869–888. 1953. PMID 13084656. 
  • "Purification and properties of hog kidney succinic thiokinase". J. Biol. Chem. 235: 2546–2550. 1960. PMID 13768680. 
  • "Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A". Biochim. Biophys. Acta 14 (3): 434–6. 1954. doi:10.1016/0006-3002(54)90205-X. PMID 13181903.—CoA ligase (GDP-forming) was the original source. Read more.