View source for Biology:TAAR9

{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
'''Trace amine-associated receptor 9''' is a [[Biology:Protein|protein]] that in humans is encoded by the ''TAAR9'' [[Biology:Gene|gene]].<ref name="pmid15718104">{{cite journal | vauthors = Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC | title = Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors | journal = Genomics | volume = 85 | issue = 3 | pages = 372–85 | date = March 2005 | pmid = 15718104 | doi = 10.1016/j.ygeno.2004.11.010 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAAR9 trace amine associated receptor 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=134860}}</ref>

TAAR9 is a member of a large family of [[Biology:Rhodopsin|rhodopsin]] G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through [[Biology:Heterotrimeric G protein|heterotrimeric G protein]]s.[supplied by OMIM]<ref name="entrez"/> N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.<ref name="pmid22545963">{{cite journal | vauthors = Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD | title = Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity | journal = ACS Chemical Biology | volume = 7 | issue = 7 | pages = 1184–9 | date = July 2012 | pmid = 22545963 | pmc = 3401279 | doi = 10.1021/cb300111e | url = }}</ref><ref name="pmid25616211">{{cite journal | vauthors = Liberles SD | title = Trace amine-associated receptors: ligands, neural circuits, and behaviors | journal = Current Opinion in Neurobiology | volume = 34 | pages = 1–7 | date = October 2015 | pmid = 25616211 | pmc = 4508243 | doi = 10.1016/j.conb.2015.01.001 }}</ref> 

TAAR9 gene deletion in rats leads to significantly decreased low-density lipoprotein cholesterol levels in the blood.<ref name="Murtazina_2021">{{cite journal | vauthors = Murtazina RZ, Zhukov IS, Korenkova OM, Popova EA, Kuvarzin SR, Efimova EV, Kubarskaya LG, Batotsyrenova EG, Zolotoverkhaya EA, Vaganova AN, Apryatin SA, Alenina NV, Gainetdinov RR | display-authors = 6 | title = Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels | journal = International Journal of Molecular Sciences | volume = 22 | issue = 6 | date = March 2021 | page = 2942 | pmid = 33799339 | pmc = 7998418 | doi = 10.3390/ijms22062942 | doi-access = free }}</ref>

== See also ==
* [[Biology:Trace amine-associated receptor|Trace amine-associated receptor]]

== References ==
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== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C | display-authors = 6 | title = Trace amines: identification of a family of mammalian G protein-coupled receptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 16 | pages = 8966–71 | date = July 2001 | pmid = 11459929 | pmc = 55357 | doi = 10.1073/pnas.151105198 | bibcode = 2001PNAS...98.8966B | doi-access = free }}
* {{cite journal | vauthors = Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF | title = Discovery of a null mutation in a human trace amine receptor gene | journal = Genomics | volume = 82 | issue = 5 | pages = 531–6 | date = November 2003 | pmid = 14559210 | doi = 10.1016/S0888-7543(03)00173-3 }}
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{{NLM content}}
{{TAAR ligands}}
{{G protein-coupled receptors}}

[[Category:G protein-coupled receptors]]



{{Sourceattribution|TAAR9}}