Biology:TAAR9
 Generic protein structure example |
Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.[1][2]
TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][2] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.[3][4]
Recent research has demonstrated that deletion of the TAAR9 gene in rats leads to significant changes in both the CNS and the periphery. In the central nervous system, knockout of this gene slightly increases hippocampal serotonin and alters grooming behavior.[5] Peripherally, blood analysis revealed decreased levels of low-density lipoprotein cholesterol in the blood.[6] Additionally, TAAR9 appears to play a significant role in maintaining microbiota homeostasis. In TAAR9-KO rats, the microbiome structure exhibited greater variability than in wild-type littermates.[7]
See also
References
- ↑ "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. March 2005. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- ↑ 2.0 2.1 "Entrez Gene: TAAR9 trace amine associated receptor 9". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=134860.
- ↑ "Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity". ACS Chemical Biology 7 (7): 1184–9. July 2012. doi:10.1021/cb300111e. PMID 22545963.
- ↑ "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology 34: 1–7. October 2015. doi:10.1016/j.conb.2015.01.001. PMID 25616211.
- ↑ Zhukov, Ilya S.; Karpova, Inessa V.; Murtazina, Ramilya Z.; Alnefeesi, Yazen; Korenkova, Olga M.; Tissen, Ilia Yu; Palchikova, Svetlana A.; Tokareva, Lydia A. et al. (12 November 2025). "TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats". Frontiers in Pharmacology 16. doi:10.3389/fphar.2025.1684029. PMID 41311835.
- ↑ "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels". International Journal of Molecular Sciences 22 (6): 2942. March 2021. doi:10.3390/ijms22062942. PMID 33799339.
- ↑ Zhukov, Ilya S.; Vaganova, Anastasia N.; Murtazina, Ramilya Z.; Alferova, Lyubov S.; Ermolenko, Elena I.; Gainetdinov, Raul R. (6 December 2022). "Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats". Biomolecules 12 (12): 1823. doi:10.3390/biom12121823. PMID 36551251.
Further reading
- "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America 98 (16): 8966–71. July 2001. doi:10.1073/pnas.151105198. PMID 11459929. Bibcode: 2001PNAS...98.8966B.
- "Discovery of a null mutation in a human trace amine receptor gene". Genomics 82 (5): 531–6. November 2003. doi:10.1016/S0888-7543(03)00173-3. PMID 14559210.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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