Biology:TAAR9
 Generic protein structure example |
Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.[1][2]
TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][2] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.[3][4]
TAAR9 gene deletion in rats leads to significantly decreased low-density lipoprotein cholesterol levels in the blood.[5]
See also
References
- ↑ "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. March 2005. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
- ↑ 2.0 2.1 "Entrez Gene: TAAR9 trace amine associated receptor 9". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=134860.
- ↑ "Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity". ACS Chemical Biology 7 (7): 1184–9. July 2012. doi:10.1021/cb300111e. PMID 22545963.
- ↑ "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology 34: 1–7. October 2015. doi:10.1016/j.conb.2015.01.001. PMID 25616211.
- ↑ "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels". International Journal of Molecular Sciences 22 (6): 2942. March 2021. doi:10.3390/ijms22062942. PMID 33799339.
Further reading
- "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America 98 (16): 8966–71. July 2001. doi:10.1073/pnas.151105198. PMID 11459929. Bibcode: 2001PNAS...98.8966B.
- "Discovery of a null mutation in a human trace amine receptor gene". Genomics 82 (5): 531–6. November 2003. doi:10.1016/S0888-7543(03)00173-3. PMID 14559210.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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