Biology:FAF1

Generic protein structure example

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.

Further reading

• "A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11894–8. 1996. doi:10.1073/pnas.92.25.11894. PMID 8524870. 
• "Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade.". Curr. Biol. 8 (18): 1001–8. 1998. doi:10.1016/S0960-9822(07)00420-4. PMID 9740801. 
• "Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins.". Mol. Cell. Biochem. 191 (1–2): 51–8. 1999. doi:10.1023/A:1006840613986. PMID 10094392. 
• "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. 2000. doi:10.1101/gr.10.5.703. PMID 10810093. 
• "The UBX domain: a widespread ubiquitin-like module.". J. Mol. Biol. 307 (1): 17–24. 2001. doi:10.1006/jmbi.2000.4462. PMID 11243799. 
• "Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites.". Int. J. Biochem. Cell Biol. 33 (6): 577–89. 2001. doi:10.1016/S1357-2725(01)00039-5. PMID 11378439. 
• "Apoptosis induced by human Fas-associated factor 1, hFAF1, requires its ubiquitin homologous domain, but not the Fas-binding domain.". Biochem. Biophys. Res. Commun. 286 (5): 1027–32. 2001. doi:10.1006/bbrc.2001.5505. PMID 11527403. 
• "FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction.". Int. J. Oncol. 19 (6): 1117–26. 2002. doi:10.3892/ijo.19.6.1117. PMID 11713579. 
• "Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter.". Nucleic Acids Res. 30 (13): 2972–9. 2002. doi:10.1093/nar/gkf390. PMID 12087183. 
• "Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.". Biochem. Biophys. Res. Commun. 297 (5): 1282–90. 2002. doi:10.1016/S0006-291X(02)02380-X. PMID 12372427. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex.". J. Biol. Chem. 278 (26): 24003–10. 2003. doi:10.1074/jbc.M302200200. PMID 12702723. 
• "Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus.". FEBS Lett. 546 (2–3): 218–22. 2003. doi:10.1016/S0014-5793(03)00575-1. PMID 12832043. 
• "The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas.". Int. J. Oncol. 23 (4): 1015–23. 2004. doi:10.3892/ijo.23.4.1015. PMID 12963981. 
• "Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB.". J. Biol. Chem. 279 (4): 2544–9. 2004. doi:10.1074/jbc.M304565200. PMID 14600157. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation.". Biochem. Biophys. Res. Commun. 320 (1): 70–5. 2004. doi:10.1016/j.bbrc.2004.05.134. PMID 15207703. 
• "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.