Biology:Mitogen-activated protein kinase kinase kinase 15

Mitogen-activated protein kinase kinase kinase 15 is a protein that in humans is encoded by the MAP3K15 gene.

Function

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.