Biology:TESK1
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Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene.[1][2]
Function
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis.[2]
Interactions
TESK1 has been shown to interact with YWHAB[3] and SPRY4.[4]
References
- ↑ "Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells". J. Biol. Chem. 270 (52): 31331–7. December 29, 1995. doi:10.1074/jbc.270.52.31331. PMID 8537404.
- ↑ 2.0 2.1 "Entrez Gene: TESK1 testis-specific kinase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7016.
- ↑ "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. November 2001. doi:10.1074/jbc.M104620200. PMID 11555644.
- ↑ "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. 269 (10): 2546–56. May 2002. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
Further reading
- "Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop". J. Biol. Chem. 274 (17): 12171–6. 1999. doi:10.1074/jbc.274.17.12171. PMID 10207045.
- "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis". Genomics 61 (1): 44–54. 1999. doi:10.1006/geno.1999.5922. PMID 10512679.
- "Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation". Mol. Biol. Cell 12 (4): 1131–45. 2001. doi:10.1091/mbc.12.4.1131. PMID 11294912.
- "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells". J. Biol. Chem. 276 (33): 31449–58. 2001. doi:10.1074/jbc.M102988200. PMID 11418599.
- "Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1". J. Biol. Chem. 276 (46): 43471–81. 2001. doi:10.1074/jbc.M104620200. PMID 11555644.
- "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". Eur. J. Biochem. 269 (10): 2546–56. 2002. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
- "Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin". J. Biol. Chem. 280 (22): 21680–8. 2005. doi:10.1074/jbc.M500752200. PMID 15817463.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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