Biology:Ferm and pdz domain containing 4

Generic protein structure example

FERM and PDZ domain containing 4 is a protein that in humans is encoded by the FRMPD4 gene.

Function

This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission.

Further reading

• "Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis". J. Neurosci. 28 (53): 14546–56. 2008. doi:10.1523/JNEUROSCI.3112-08.2008. PMID 19118189. 
• "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121. 
• "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care 33 (10): 2250–3. 2010. doi:10.2337/dc10-0452. PMID 20628086. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.