Biology:Colon cancer associated transcript 1 (non-protein coding)
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Colon cancer associated transcript 1 (non-protein coding) is a protein that, in humans, is encoded by the CCAT1 gene. [1][2]
This gene produces a long non-coding RNA that promotes tumor formation and is upregulated in colon cancer and other cancer cell types.[3] This transcript may regulate long range chromosomal interactions, including at the Myc oncoprotein locus[4]. This RNA may also function as a molecular sponge for microRNAs[5].
References
- ↑ "Entrez Gene: Colon cancer associated transcript 1 (non-protein coding)". https://www.ncbi.nlm.nih.gov/gene/100507056. Retrieved 2017-03-16.
- ↑ "CCAT2 colon cancer associated transcript 2 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=101805488.
- ↑ "CCAT1 Gene - GeneCards | CCAT1 RNA Gene". https://www.genecards.org/cgi-bin/carddisp.pl?gene=CCAT1.
- ↑ "CCAT1 colon cancer associated transcript 1 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=100507056.
- ↑ "CCAT1 Gene - GeneCards | CCAT1 RNA Gene". https://www.genecards.org/cgi-bin/carddisp.pl?gene=CCAT1.
Further reading
- "Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma". J. Cancer Res. Clin. Oncol. 139 (3): 437–45. 2013. doi:10.1007/s00432-012-1324-x. PMID 23143645.
- "Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence". BMC Cancer 13: 196. 2013. doi:10.1186/1471-2407-13-196. PMID 23594791.
- "Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus". Cell Res. 24 (5): 513–31. 2014. doi:10.1038/cr.2014.35. PMID 24662484.
- "Long non-coding RNA CARLo-5 is a negative prognostic factor and exhibits tumor pro-oncogenic activity in non-small cell lung cancer". Tumour Biol. 35 (11): 11541–9. 2014. doi:10.1007/s13277-014-2442-7. PMID 25129441.
- "Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p". Cell Death Dis 6: e1583. 2015. doi:10.1038/cddis.2014.541. PMID 25569100.
- "Enhanced expression of long noncoding RNA CARLo-5 is associated with the development of gastric cancer". Int J Clin Exp Pathol 7 (12): 8471–9. 2014. PMID 25674211.
- "Pan-cancer transcriptome analysis reveals long noncoding RNAs with conserved function". RNA Biol 12 (6): 628–42. 2015. doi:10.1080/15476286.2015.1038012. PMID 25864709.
- "Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge". J. Exp. Clin. Cancer Res. 34: 18. 2015. doi:10.1186/s13046-015-0136-7. PMID 25884472.
- "CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion". Int J Clin Exp Pathol 8 (5): 5427–34. 2015. PMID 26191246.
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