Biology:Peripolesis
Peripolesis is the process in which a cell attaches itself to another cell. This is differentiated from emperipolesis, which is when one cell is engulfed by another. Peripolesis is thought to be a physiological mechanism involved in regulating some processes of immune response. It was observed between lymphocytes and macrophages following skin grafts between subjects, and after immune challenge with antigens.[1] Peripolesis was also observed in lung alveoli, where the peripolesed macrophages were not injured, but the cell membrane did appear to be temporarily altered.[2] In patients with active sarcoidosis, which is characterized by lymphocyte-macrophage cooperation, lymphocyte peripolesis appeared to occur in clusters and could last for minutes to hours. The lymphocytes could be seen moving around a macrophage while maintaining contact.[3]
References
- ↑ Sharp, J. A.; Burwell, R. G. (1960-11-05). "Interaction ('Peripolesis') of Macrophages and Lymphocytes after Skin Homografting or Challenge with Soluble Antigens" (in en). Nature 188 (4749): 474–475. doi:10.1038/188474a0.
- ↑ "Lymphocyte macrophage interactions: peripolesis of human alveolar macrophages". European Respiratory Journal 5 (1): 59–66. Jan 1992. PMID 1577151.
- ↑ van Maarsseveen, Ton C.; de Groot, Jan; Stam, Jaap; van Diest, Paul J. (1993-05-01). "Peripolesis in Alveolar Sarcoidosis". American Review of Respiratory Disease 147 (5): 1259–1263. doi:10.1164/ajrccm/147.5.1259. ISSN 0003-0805. PMID 8484640.
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