Biology:Keratin 2A
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Keratin 2A also known as keratin 2E or keratin 2 is a protein that in humans is encoded by the KRT2A gene.[1][2]
Keratin 2A is a type II cytokeratin. It is found largely in the upper spinous layer of epidermal keratinocytes and mutations in the gene encoding this protein have been associated with ichthyosis bullosa of Siemens.[3]
References
- ↑ "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation". Exp. Cell Res. 202 (1): 132–41. September 1992. doi:10.1016/0014-4827(92)90412-2. PMID 1380918.
- ↑ "Genomic organization and fine mapping of the keratin 2e gene (KRT2E): K2e V1 domain polymorphism and novel mutations in ichthyosis bullosa of Siemens". J. Invest. Dermatol. 111 (5): 817–21. November 1998. doi:10.1046/j.1523-1747.1998.00371.x. PMID 9804344.
- ↑ "Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens". Nat. Genet. 7 (4): 485–90. August 1994. doi:10.1038/ng0894-485. PMID 7524919.
Further reading
- "New mutations in keratin 1 that cause bullous congenital ichthyosiform erythroderma and keratin 2e that cause ichthyosis bullosa of Siemens.". Br. J. Dermatol. 145 (2): 330–5. 2001. doi:10.1046/j.1365-2133.2001.04327.x. PMID 11531804.
- "Suprabasal induction of ornithine decarboxylase in adult mouse skin is sufficient to activate keratinocytes.". J. Invest. Dermatol. 124 (3): 602–14. 2005. doi:10.1111/j.0022-202X.2005.23620.x. PMID 15737202.
- "A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens.". J. Invest. Dermatol. 114 (1): 193–5. 2000. doi:10.1046/j.1523-1747.2000.00817.x. PMID 10620137.
- "Expression of Keratin K2e in Cutaneous and Oral Lesions : Association with Keratinocyte Activation, Proliferation, and Keratinization". Am. J. Pathol. 162 (3): 963–75. 2003. doi:10.1016/S0002-9440(10)63891-6. PMID 12598329.
- "Ichthyosis bullosa of Siemens: report of a family with evidence of a keratin 2e mutation, and a review of the literature". Br. J. Dermatol. 140 (4): 689–95. 1999. doi:10.1046/j.1365-2133.1999.02772.x. PMID 10233323.
- "Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development". Br. J. Dermatol. 140 (4): 582–91. 1999. doi:10.1046/j.1365-2133.1999.02755.x. PMID 10233306.
- "Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens". Exp. Dermatol. 9 (1): 11–5. 2000. doi:10.1034/j.1600-0625.2000.009001011.x. PMID 10688369.
- "A novel H1 domain mutation in the keratin 2 gene in a Japanese family with ichthyosis bullosa of Siemens". Br. J. Dermatol. 156 (5): 1042–4. 2007. doi:10.1111/j.1365-2133.2007.07832.x. PMID 17408392.
- "A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens". J. Invest. Dermatol. 112 (3): 380–2. 1999. doi:10.1046/j.1523-1747.1999.00529.x. PMID 10084318.
- "Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing". Br. J. Dermatol. 152 (6): 1353–6. 2005. doi:10.1111/j.1365-2133.2005.06598.x. PMID 15949009.
- "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. 2006. doi:10.1083/jcb.200603161. PMID 16831889.
- "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics 7 (3): 499–508. 2008. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
- "A glutamate to lysine mutation at the end of 2B rod domain of keratin 2e gene in ichthyosis bullosa of Siemens". Acta Derm. Venereol. 78 (6): 417–9. 1998. doi:10.1080/000155598442683. PMID 9833038.
- "Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity". FEBS Lett. 577 (1–2): 93–100. 2004. doi:10.1016/j.febslet.2004.09.069. PMID 15527767.
- "Ichthyosis bullosa of Siemens resulting from a novel missense mutation near the helix termination motif of the keratin 2e gene". Clin. Exp. Dermatol. 24 (5): 412–5. 1999. doi:10.1046/j.1365-2230.1999.00514.x. PMID 10564334.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A novel mutation in the 2B domain of keratin 2e causing ichthyosis bullosa of Siemens". Clin. Exp. Dermatol. 25 (8): 648–51. 2000. doi:10.1046/j.1365-2230.2000.00728.x. PMID 11167982.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "HDM2-binding partners: interaction with translation elongation factor EF1alpha". J. Proteome Res. 6 (4): 1410–7. 2007. doi:10.1021/pr060584p. PMID 17373842.
External links
- Keratin-2 at the US National Library of Medicine Medical Subject Headings (MeSH)
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