Biology:Delta-like 1

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[1]

Function

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[1]

Interactions

Delta-like 1 has been shown to interact with NOTCH2[2][3][4]

References

  1. 1.0 1.1 "Entrez Gene: DLL1 delta-like 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514. 
  2. "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. July 2001. doi:10.1074/jbc.M103473200. PMID 11346656. 
  3. "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell 90 (2): 281–91. July 1997. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302. 
  4. "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. September 2000. doi:10.1128/mcb.20.18.6913-6922.2000. PMID 10958687. 

Further reading